脂联素在缺血性脑损伤中作用的研究进展  

Research advances of adiponectinin cerebral ischemic injury

作　　者：孙思斯 王百忍[1] 王强[1] 陈绍洋[1] 

机构地区：[1]第四军医大学西京医院麻醉科,西安710032

出　　处：《国际麻醉学与复苏杂志》2014年第6期546-549,566,共5页International Journal of Anesthesiology and Resuscitation

摘　　要：背景 脂联素是一种由脂肪分泌的脂肪因子,在代谢过程中发挥重要作用,可增加胰岛素的敏感性、氧化葡萄糖以及脂肪.最近报道显示脂联素也可以减轻动脉粥样硬化,降低炎症反应,减轻心肌缺血/再灌注损伤,同样具有神经保护作用. 目的 将就近期血浆脂联素作为缺血性脑卒中发生风险和预后评价因子的相关临床研究以及外源性脂联素神经保护作用机制探索的基础研究进行总结. 内容 描述了脂联素的结构功能、生理作用,并对其与缺血性脑卒中相关的临床实验、基础研究予以总结. 趋向 多数临床实验数据显示低血浆脂联素水平与缺血性脑卒中高发生率、较差预后密切相关;而且一系列基础实验证实外源性补充脂联素能够诱导神经保护.Background Adiponeetin, an adipokine secreted by different adipocytes, has been known to play pivotal roles in metabolisms including insulin sensitization, oxidation of glucose and lipids. Recently, it has been reported that adiponeetin can also attenuate the process of atherosclerosis, decrease the inflammatory response, protect myocardia against ischemic reperfusion injury, and provide neuroprotection. Objective To review the related clinical studies of adiponection as a factor to assess the risk and the prognosis of ischemic stroke and basic studies about the mechanism of exogenous adiponeetin induced neuroprotection against ischemic stroke injury. Content In present review, we described the recent advances in the relationship between serum adiponeetin and occurrence of ischemic stroke in clinic trials and the mechanism of neuroprotection induced by supplement of adiponectin. Trend Mounting clinical studies indicate that low level of serum adiponectin is associated with high incidence and poor outcome of isehemic stroke. Furthermore, some basic researches also demonstrate the neuroprotective effects of exogenous adipokine.

关 键 词：脂联素 脑卒中 脑缺血 再灌损伤 

分 类 号：R743[医药卫生—神经病学与精神病学]