抑癌基因P16在肺癌中的研究进展  

Progress of Tumor Suppressor Gene P16 in Lung Cancer

作　　者：高越[1] 叶磊光[1] 李娜[2] 关雪晴[1] 刘宝刚[1] 

机构地区：[1]哈尔滨医科大学附属肿瘤医院,黑龙江哈尔滨150081 [2]辽宁医学院附属三院,辽宁锦州121000

出　　处：《现代生物医学进展》2014年第20期3964-3966,共3页Progress in Modern Biomedicine

基　　金：黑龙江省自然科学基金项目(D201238)

摘　　要：抑癌基因P16与细胞周期调控密切相关,其主要作用是参与细胞周期过程,它通过细胞周期与其它癌基因及肿瘤抑制基因相互作用成为正常细胞增殖的调控因子。P16基因主要通过基因缺失、点突变及甲基化而失活,已证实该基因的失活与多种肿瘤的形成与转移密切相关。通过各种分子生物学技术检测出它在肿瘤中的表达,将有助于判断肿瘤的恶性程度、浸润深度及预后,为制定合理的治疗方案提供依据。P16是已知的抑癌基因中唯一通过直接抑制细胞周期而抑制细胞生长的基因,在肿瘤治疗方面有很大的应用前景。P16基因突变在人类恶性肿瘤中普遍存在,因此,有关p16基因的研究已经成为当前分子生物学和分子遗传学研究的重要课题。本文就p16基因的分子生物学特性及它与肺癌的关系作一综述。Tumor suppressor gene p16 is closely related to cell cycle regulate, its main action is participate in the process of cell cycle. It is become regulatory factor of normal cell multiplication by means of interaction with cell cycle and oncogene and tumor suppressor gene. P16 is mainly deactivated through gene deletion, point mutation and methylation. It has proved that p16 deactivation is closely related to formation and metastasis of multi-tumor. Detecting the expression of p 16 in tumor by all kinds of molecular biological techniques will contribute to identify grademaliguancy, invasion depth and prognosis which provide reasonable basics for treatment plan. P16 is known as the only anti-oneogene which through suppression cell cycle directly to depression cell growth. It has a tremendous application prospect in oncotherapy. Gene p16 mutation generally exists in human malignant tumor. Thus, research on gene p16 has already been important subject of molecular biology and molecular genetics. This general is about the reletionship between molecular biology of gene p16 and lung cancer.

关 键 词：肺癌 抑癌基因 P16 甲基化 

分 类 号：R734.2[医药卫生—肿瘤]