骨髓来源细胞参与眼部新生血管形成的分子机制  

Molecular mechanism of bone marrow-derived cells in the development of ocular neovascularization

作　　者：高凡[1] 王雨生[1] 侯慧媛[1] 

机构地区：[1]第四军医大学西京医院眼科全军眼科研究所,西安710032

出　　处：《国际眼科纵览》2014年第3期164-169,共6页International Review of Ophthalmology

基　　金：国家自然科学基金项目（81200708,81070748,81200151）;第四军医大学青年英才项目（2012-2014）;国家重点基础研究发展计划（2011CB510200）

摘　　要：眼部新生血管是多种眼病引发视力障碍的重要原因.骨髓来源细胞（bone marrow-derived cells,BMC）经动员、迁移、黏附和分化等步骤参与其中,受衰老、吸烟等危险因素影响,是一个复杂的需要精确调控的过程.目前,BMC参与眼部新生血管形成的分子机制已成为研究的热点和难点,阐明其中的机制对了解眼部新生血管发生及以BMC为靶点的临床疾病治疗探索具有重要意义.Ocular neovascularization is a significant contributor to visual impairment in many eye diseases.Bone marrow-derived cells （BMCs） play important roles in the development of ocular neovascularization,in which BMCs are believed to undergo the steps of mobilization,migration,adhesion and differentiation.This process is delicately regulated and affected by multiple factors,including aging,smoking,and so on.Now it has become a research hotspot to investigate the molecular mechanism of BMCs involved ocular neovascularization,which is imperative for further studies on pathogenesis of ocular neovascularization and treatment strategies using BMCs as targets.

关 键 词：眼部新生血管 骨髓来源细胞 分子机制 

分 类 号：R771[医药卫生—眼科]