急性髓细胞白血病CD11b表达的临床意义  

Cliniacl significance of CD11b expression in acute myeloid leukemia

作　　者：梁建英[1] 张宏[1] 常英军[1] 虞斐[1] 邹正辉[1] 

机构地区：[1]苏州大学附属第二医院,215004

出　　处：《江苏医药》2001年第4期259-260,共2页Jiangsu Medical Journal

摘　　要：目的　研究急性髓细胞白血病 (AML)CD11b表达的临床意义。方法　采用碱性磷酸酶抗碱性磷酸酶复合物法 (APAAP) ,测定 80例AML患者细胞膜表面CD11b的阳性表达。结果　CD11b+AML缓解率 ( 44 4% )明显低于D11b-AML缓解率 ( 73 8% ) (P <0 0 5 ) ,CD11b+AML患者平均生存期明显低于CD11b-AML患者 (P <0 0 1) ,且与年龄、白细胞数、细胞遗传学异常等因素无关。结论　CD11b表达是AML预后不良的特征之一。Objective To investigate the clinical significance of CD11b expression in acute myeloid leukemia(AML).Methods Expression of CD11b in 80 AML patients was measured by alkaline phosphatase anti alkaline phosphotase complex methods (APAAP).Results The complete remission rate of CD11b + AML(44 4%) was significantly( P< 0 05) lower than that of CD1b -AML(73 8%),which had no correlation with age,leucocyte counts,cytogenetic abnormalities and so on.Conclusion CD11b is a new clinical feature which indicates that the patients have a poor prognosis.

关 键 词：急性髓细胞白血病 CD11B 预后 免疫表型 核型分析 抗体 

分 类 号：R733.71[医药卫生—肿瘤]