基于二分图和贪婪算法的方剂配伍设计方法研究  

Study on prescription combination and design method based on dichotomy and greedy algorithm

作　　者：董昉[1] 李晓鹤[1] 过红玲[1] 陶欧[1] 王耘[1] 乔延江[1] 

机构地区：[1]北京中医药大学中药信息工程研究中心,北京100102

出　　处：《中国中药杂志》2014年第13期2386-2388,共3页China Journal of Chinese Materia Medica

基　　金：国家科技支撑计划项目(2008BAI51B01);国家自然科学基金项目(81373985;81173568);教育部新世纪优秀人才支持项目(NECT-11-0605);北京中医药大学科研创新团队支持项目(2011-CXTD-11)

摘　　要：中药方剂配伍讲究性味归经和气机沉降,根据多种配伍原则和多味药的性味配合进行配伍。随着研究的深入,研究者们认识到药性理论是中药配伍的核心原理,但目前还未有明确的方法指出如何基于药性进行配伍。该文提出了一套基于二分图和贪婪算法的方剂配伍设计方法,通过以四味鹿茸丸的药性组合模式为模板组出新方为例,证明该方法可为方剂配伍提供快速选药的思路,并讨论了此方法用于替代珍惜濒危药材和禁用药材的前景。The prescription combinations of traditional Chinese medicine （TCM） focuses on the taste and channel tropism, the Qi movement, as well as the compatibility according to multiple combination principles and medicinal property and flavor combination of several traditional Chinese medicines. With the in-depth study on the prescription compatibility, researchers have realized that the me- dicinal property theory is the core of TCM combinations. However, there is no definite method for combinations based on medicinal properties. In this paper, the authors put forward an method for designing prescription combinations based on bipartite graph and the greedy algorithm. With the medicinal property combinations of Siweilurong Pills for example, the authors proved this method could provide ideas for quickly choosing herbal medicines for prescription combinations, and discussed the prospect of this method in substituting previous and endangered herbal medicines and banned medicinal materials.

关 键 词：方剂配伍 二分图 贪婪算法 药性组合模式 

分 类 号：R289[医药卫生—方剂学]