supported by the National Natural Science Foundation of China(82072247 and 82374154);National Key Research and Development Project of China(2022YFC3502300);Natural Science Foundation of Beijing Municipality(L222150);Tianjin Chasesun Pharmaceutical(BUCM-2022-JS-FW-076);Zhuhai Yourun Co.,Ltd.(BUCM-2023-JS-KF-018)
目的:筛选中药活性成分作为鼠伤寒沙门氏菌致病性岛III(Salmonella pathogenicity island III,SPI-3)潜在毒力抑制剂。方法:通过分子对接技术明确中药成分与SPI-3中的MgtC蛋白的潜在结合关系。使用β-半乳糖苷酶测定法评估中药成分对mgt...