ICP-MS测定诃子炮制前后无机元素含量及安全性评价  

Determination of Inorganic Element Content and Safety Evaluation of Terminalia chebula before and after Processing by ICP-MS

作　　者：李华爽 姜媛媛 余少君 叶婉婷 马涛[1] 陶欧[1] 刘永刚[1] LI Hua-shuang;JIANG Yuan-yuana;YU Shao-jun;YE Wan-ting;MA Tao;TAO Ou;LIU Yong-gang(Beijing University of Chinese Medicine,Beijing 100029,China;Bei Gene,Ltd.,Beijing 100022,China)

机构地区：[1]北京中医药大学,北京100029 [2]百济神州(北京)生物科技有限公司,北京100022

出　　处：《中国现代中药》2024年第5期848-855,共8页Modern Chinese Medicine

基　　金：国家自然科学基金重点项目(82130113)。

摘　　要：目的:建立诃子生品及清炒、麸煨、砂烫、烘制4种炮制品中26个无机元素的分析方法,对其中重金属及有害元素进行健康风险评估。方法:采用电感耦合等离子体质谱法,以铑和铼为内标,通过标准曲线法测定诃子中的26个元素;采用危害指数(HI)法和暴露限值(MOE)法进行健康风险评估。结果:26个元素的标准曲线线性关系良好,仪器检出限为0.0002~0.4342μg·kg^(-1),加样回收率为83.21%~116.84%。诃子炮制前后无机元素差异明显,部分重金属及有害元素所致健康风险较低。结论:该方法简便、准确,适用于诃子中无机元素的含量测定,为其重金属及有害元素健康风险评估提供了参考。Objective:A method was established to analyze 26 inorganic elements in raw products,stir-fried products without adjuvant,stir-fried products with bran,products scalded with sand,and baked products of Terminalia chebula.The health risk of heavy metals and harmful elements in T.chebula were assessed.Methods:By using inductively coupled plasma-mass spectrometry(ICP-MS),the 26 elements were determined by the standard curve method with rhodium and rhenium as internal standards;the hazard index(HI)method and the limit of exposure(MOE)method were used for health risk assessment.Results:The standard curves for the 26 elements exhibited excellent linear relationships,with instrumental detection limits varying from 0.0002 to 0.4342μg·kg^(-1),and the spiked recoveries of 83.21%-116.84%.Notable distinctions in inorganic elements in T.chebula before and after processing were observed.Some heavy metals and harmful elements posed a low risk to human health.Conclusion:The method is accessible,precise,and well-suited for determining inorganic element content in T.chebula,providing a reference for health risk assessment of heavy metals and harmful elements.

关 键 词：诃子 电感耦合等离子体质谱法 炮制 无机元素 重金属及有害元素 风险评估 

分 类 号：R284[医药卫生—中药学]