序贯放化疗与同步放化疗治疗结直肠癌临床疗效比较分析  

作　　者：张庆忠[1] 

机构地区：[1]河南省濮阳市人民医院,河南457000

出　　处：《当代医学》2014年第19期54-55,共2页Contemporary Medicine

摘　　要：目的对比序贯放化疗和同步放化疗用于结直肠癌治疗的临床效果。方法回顾性分析河南省濮阳市人民医院60例结直肠癌患者临床资料,其中Ⅱ期患者20例,依照入院顺序随机平均分为A组和B组;Ⅲ期患者40例,依照入院顺序随机平均分为C组和D组,A、C组予以序贯放化疗,B、D组予以同步放化疗,对比A、C组和B、D组疗效。结果Ⅱ期序贯、同步放化疗临床效果对比2组各阶段总生存率及无进展生存率无差异。A、B组各阶段总生存率及无进展生存率无差异,D组同步放化疗后1年总生存率、无进展生存率分别为90%、80%,3年总生存率、无进展生存率分别为70%、55%,均明显高于C组(P<0.05)。A、C组序贯放化疗与B、D组对应毒副作用发生率对比无差异。结论同步放化疗方案治疗Ⅲ期结直肠癌生存率更高、毒副作用与序贯放化疗方案相当,安全有效。Objective To compare the sequential chemoradiotherapy andconcurrent chemoradiotherapy for treatment of rectal cancer.Methods A total of 60 cases of patients with colorectal cancer, 20 cases of stage II patients,divided into A group and B group; 40 cases in stage III patients, divided into C group and D group, A, C group was treated with sequential chemotherapy, B, D group was treated with radiotherapy and chemotherapy. Results The totalsurvival rate of A, B group of each stage and progression free survival was no difference , D group of 1 years, 3 year overall survival, progression free survival rate was significantly higher than that in C group （P〈0.05）. A, B, C group and D group, the incidence of adverse effects compared with no difference.Conclusion Radiotherapy and chemotherapy in the treatment of stage III colorectal cancer survival rate is higher, side effects andsequential chemotherapy scheme.

关 键 词：序贯和同步 放化疗 结直肠癌 疗效 

分 类 号：R735.34[医药卫生—肿瘤] R730.55[医药卫生—临床医学]