ABCA1 R219K基因多态性与脑梗死合并2型糖尿病的关系  

Association between ABCA1 R219K gene polymorphisms and cerebral infarction with type 2 diabetes

作　　者：陈卫蓉[1] 肖志杰[2] 周中华[2] 邓可[2] 

机构地区：[1]长沙市妇幼保健院,410011 [2]中南大学湘雅二医院神经内科

出　　处：《卒中与神经疾病》2014年第3期136-138,共3页Stroke and Nervous Diseases

摘　　要：目的探讨ABCA1 R219K基因多态性与脑梗死合并2型糖尿病的关系。方法采用病例对照方法,对279例脑梗死患者和351例健康对照者进行研究。采用多聚酶链式反应(polymerase chain reaction,PCR)和限制性片段长度多态性测定ABCA1 R219K基因多态性。结果脑梗死组合并糖尿病的患者比例高于对照组合并糖尿病的患者比例,合并糖尿病组的TG、TC水平高于无糖尿病组(P<0.05)。脑梗死与健康对照各组间ABCA1 R219K各个基因型分布频率比较,无显著差异(P>0.05)。结论 ABCA1 R219K基因多态性与脑梗死合并2型糖尿病无明显关系。Objective To investigate the relationship between ABCA1 R219K Gene Polymorphisms and cerebral infarction with type 2 diabetes. Methods A case-control study on 279 patients with cerebral infarction and 351 healthy controls was carried out. The genotype and allele frequencies of r219k gene polymorphism were assayed by polymerase chain reaction-restricted fragments length polymorphism （PCR-RFLP）. Results Diabetes was more common in cerebral infarction group then in control group. TG, TC levels were higher in cerebral infarction with diabetes patients than in those without diabetes group（P〈0. 05）. Conclusions There were no statistical significant difference for ABCA1 R219K genotype frequencies between Cerebral infarction and healthy control （P〉0. 05）.

关 键 词：三磷酸腺苷结合盒转运体 R219K 基因多态性 脑梗死 

分 类 号：R743[医药卫生—神经病学与精神病学] R587.1[医药卫生—临床医学]