ZFX在小细胞肺癌组织中的表达及临床意义  

Expression and clinical significance of ZFX in tissues from small cell lung cancer patients

作　　者：苏文媚[1] 武奋萍[1] 罗亮[1] 许贝[1] 杨志雄[1] 赖振南[1] 

机构地区：[1]广东医学院附属医院肿瘤中心,广东湛江524000

出　　处：《中国癌症杂志》2014年第6期418-422,共5页China Oncology

摘　　要：背景与目的:小细胞肺癌(small cell lung cancer,SCLC)约占全部肺癌的15%,化疗是其主要的治疗方法之一,虽然早期对一线化疗方案敏感,但极易出现多药耐药而导致治疗失败。前期基因芯片发现X染色体耦联锌指蛋白(zinc finger protein X-linked,ZFX)在SCLC细胞中异常高表达,本研究进一步检测SCLC患者组织中ZFX的表达,并分析其与患者临床病理特征的关系,为SCLC的治疗提供依据。方法:收集在广东医学院附属医院肿瘤中心行支气管镜活检及手术切除的SCLC组织标本98例,采用QRT-PCR方法从基因水平检测其中临床资料完整的78例SCLC标本中ZFX的表达。结果:在78例SCLC组织标本中,ZFX在广泛期的SCLC组织中的表达较局限期患者的表达明显增高,差异有统计学意义(P<0.05)。ZFX的表达与患者性别、年龄无关(均P>0.05);而与肿瘤的分期、对化疗药物的敏感性及总生存时间相关(均P<0.001)。结论:ZFX的表达可能和SCLC发生、发展相关,ZFX的检测有望作为SCLC的预后指标。Background and purpose：Lung cancer is the leading cause of cancer-related deaths worldwide. Approximately 15%of all histological types consist of small cell lung cancer （SCLC）. Chemotherapy is one of the major treatment methods. Though the current front-line standard chemotherapy regimen for SCLC is active in most SCLC cases, however, the disease recurs shortly after the ifrst successful treatment with multi-drug resistance phenotype. Our previously study showed that zinc ifnger protein X-linked （ZFX） was overexpressed in SCLC cells. This study aimed to investigate the expression of ZFX in SCLC tissues, and to clear their possible associations with clinical parameters and provide basis for therapy of SCLC. Methods：A total of 98 surgical specimens of small cell lung cancer were collected. The expression of ZFX was examined by quantiifcational real-time polymerase chain reaction in 78 specimens taken from patients with complete clinical data. Results：The expression of ZFX was signiifcantly increased in extensive stages than in limited stages. The expression of ZFX was associated with tumor stage, the sensitivity of chemotherapy, and survival times （all P0.05）. Conclusion： ZFX expression might be associated with the development of SCLC, and may be a potential prognosis predictor.

关 键 词：SCLC X染色体耦联锌指蛋白 临床病理参数 

分 类 号：R734.2[医药卫生—肿瘤]