肿瘤相关循环游离核酸的研究进展  

Recent advances in cancer-associated circulating cell-free nucleic acids

作　　者：邢星[1,2] 刘勇 孙勇[3,2] 周鑫 胡超苏[1,2] 

机构地区：[1]复旦大学附属肿瘤医院放疗科 [2]复旦大学上海医学院肿瘤学系,上海200032 [3]复旦大学附属肿瘤医院肿瘤研究所

出　　处：《中国癌症杂志》2014年第6期469-475,共7页China Oncology

摘　　要：循环游离核酸是指存在于人体血液循环中,游离于细胞外的微量内源性或外源性核酸片段。肿瘤患者的血液中游离核酸的含量明显高于健康人群,并具有与肿瘤的发生、发展相关的特征性改变,如基因突变、甲基化、杂合性丢失、片段完整性改变、microRNA的异常表达等。对血液中游离核酸的定性与定量检测,在肿瘤的筛查、诊断、个体化治疗方案的制定、病情的监测以及预后评价中均有潜在的价值。Circulating cell-free nucleic acids are defined as extracellular DNAs or RNAs in blood with physiological or pathological origins. Previous studies showed that the concentration of cell-free nucleic acids in the blood of cancer patients is significantly higher than in healthy people. Further studies showed that the genetic and epigenetic alterations of circulating cell-free nucleic acids are relevant to cancer development and progression, including mutation, hypermethylation, loss of heterozygosity, change of integrity, and abnormal expression of microRNAs. Detection of circulating cell-free nucleic acids shows promising potential in cancer screening, diagnosis, personalized treatment, and prognosis.

关 键 词：肿瘤 循环游离核酸 肿瘤标志物 

分 类 号：R730.3[医药卫生—肿瘤]