HER-2、CyclinD1在甲状腺乳头状癌中的表达及意义  

Expression and significance of HER-2 and CyclinD1 in papillary thyroid carcinoma

作　　者：张晓亮[1,2] 胡向阳[1,2] 杨懿[2] 丁婧[1,2] 汪巧[1,2] 

机构地区：[1]安徽医科大学病理学教研室,合肥230032 [2]安徽医科大学第一附属医院病理科,合肥230022

出　　处：《安徽医科大学学报》2014年第7期958-962,共5页Acta Universitatis Medicinalis Anhui

基　　金：国家临床重点专科建设项目经费资助

摘　　要：目的探讨HER-2、CyclinD1蛋白表达在甲状腺乳头状癌(PTC)中的意义。方法采用免疫组化Envision法检测97例PTC以及癌旁甲状腺良性病变组织中的HER-2、CyclinD1蛋白表达状况。结果 1 HER-2在PTC中的阳性表达率为46.4%,在癌旁良性病变中未见表达,差异有统计学意义(P<0.05);HER-2阳性表达与肿瘤大小相关,即其在≤1 cm与>1 cm的PTC间表达差异显著,与其他临床病理参数无相关性。2 CyclinD1在PTC中的阳性表达率为92.8%,在癌旁良性病变中未见表达,差异均有统计学意义(P<0.05),其在PTC中灵敏度为92.8%、特异度达100%,与临床病理参数无相关性。CyclinD1在一些患者癌组织中癌细胞的表达上存在异质性。3 HER-2与CyclinD1在PTC中表达无相关性。结论 1 HER-2蛋白表达是PTC发生发展的一项重要事件,HER-2可能作为PTC靶向治疗的靶点。2 CyclinD1可以作为PTC早期诊断的分子标志物,CyclinD1的异质性表达可能与淋巴转移相关。Objective To explore the significance of HER-2 protein, CyclinD1 protein in papillary thyroid carcinoma （ PTC） . Methods Immunohistochemical staining was performed in 97 specimens of PTC and 97 specimens of adjacent benign lesions to examine the expression of HER-2 protein and CyclinD1 protein. Results ① The positive ratio of HER-2 in PTC was 46. 4%, and no expression in the adjacent benign lesions. There was statistical difference between them （ P 〈0. 05 ） . HER-2 expression correlated with tumor size in PTC. The expression of HER-2 had significant difference between less than or equal to 1 cm and greater than 1cm in diameter of PTC. There were no relationships between expression of HER-2 and other clinicopothological features in PTC. ② The positive ratio of CyclinD1 in PTC was 92. 8%, and no expression in the adjacent benign lesions. There was statistical difference between them（P〈0. 05）. The sensitivity of CyclinD1 was 92. 8%, the specificity can reach 100%in PTC . There were no relationships between expression of CyclinD 1 and the clinicopothological features in PTC .CyclinD1 showed heterogeneity of expression in some patients’ carcinoma. ③There were no relationships between expression of HER-2 and CyclinD1 in PTC. Conclusion ① HER-2 plays an important role in the carcinogenesis of PTC. HER-2 could be a potential target for targeted therapy in PTC. ②CyclinD1 could be as molecular markers of early diagnosis in PTC. There could be positive correlation between CyclinD1 ’ s heterogeneity of expression of PTC and the lymph node metastases.

关 键 词：甲状腺乳头状癌 HER-2 C-ERBB-2 CYCLIND1 

分 类 号：R736.1[医药卫生—肿瘤]