大肠癌组织miRNA205表达及临床意义分析  

Expression of miRNA205 in colorectal cancer tissue and its clinical significance

作　　者：陈昌裕[1] 余昌俊[1] 张敏[2] 谭胜[2] 龙腾云[1] 朱正杰[1] 欧阳欢[1] 

机构地区：[1]安徽医科大学第一附属医院胃肠外科,合肥230022 [2]中国科学技术大学生命科学院,合肥230026

出　　处：《安徽医科大学学报》2014年第7期1016-1018,共3页Acta Universitatis Medicinalis Anhui

基　　金：国家自然科学基金(编号:31201022)

摘　　要：应用实时定量PCR法检测miRNA205在37对大肠癌组织及远端正常黏膜中的表达,用graphpad软件t检验分析miRNA205在大肠癌中的表达差异及与临床各病理参数的关系。与癌旁组织比较,miRNA205在大肠癌组织中明显低表达,差异有统计学意义,但miRNA205在大肠癌中的表达水平与临床各病理参数(性别、年龄、肿瘤浸润深度、细胞分化、淋巴结转移)无明显相关性。Real-time PCR was used to analyze the expression of miRNA205 , paired t test and unpaired t test of graphpad was used to analyze the different expression between cancer tissues and normal tissues and the relationship between miRNA205 expression and clinicalpathological characteristics. The expression of miRNA205 of the 37 cancers was significantly different from the normal ones, but there was no significant correlation between the miRNA205 expression levels and clinicalpathological characteristics（ gender, age, depth of invasion, cell differentiation, lymph node metastasis） .

关 键 词：大肠癌 miRNA205 PCR 

分 类 号：R735.34[医药卫生—肿瘤]