81例青年肺癌的临床与预后因素分析  

Eighty-one Cases of Young People with Lung Cancer: a Study of the Clinical and Prognostic Factors Characteristics

作　　者：任剑飞[1] 汤耀东[1] 陈士勇[2] 何一兵[1] 宋美君[1] 徐慧[1] 林志辉[1] 

机构地区：[1]宁波大学医学院附属宁波市医疗中心李惠利医院呼吸内科,315041 [2]宁波大学医学院附属宁波市医疗中心李惠利医院统计室,315041

出　　处：《医学研究杂志》2014年第6期125-128,共4页Journal of Medical Research

摘　　要：目的 探讨青年肺癌的临床特点、预后分析.方法 回顾2008年1月～2013年9月81例青年肺癌的临床特点,结合预后因素进行分析.结果 青年肺癌中21例体检时发现,60例有临床症状,表现为咳嗽占78.3％、胸痛占38.3％、气促占13.3％,痰血占11.7％.Ⅰ期23例,占28.3％,Ⅱ期3例,占3.7％,Ⅲ期14例,占17.4％,Ⅳ期41例,占50.6％.淋巴结转移占39.5％,心包、胸腔转移占30.9％,肺内转移占16.5％,骨骼转移占12.3％.癌胚抗原（carcinoembryonic antigen,CEA）值平均为25.0±8.2μg/ml.青年肺癌中吸烟者、非吸烟者中位生存期,无统计学差异（P＞0.05）,而性别、淋巴结有或无转移、分期Ⅰ～Ⅱ、Ⅲ、Ⅳ、根治手术或姑息治疗、腺癌或非腺癌、CEA正常组或升高组、体检者或症状者7组生存期,均有统计学差异（P＜0.05）.1年生存率为56.2％,3年生存率为15.4％.结论 青年肺癌临床表现特异性差,恶性程度高,易出现淋巴结、胸腔、心包、肺内等转移,与吸烟无相关性,有症状出现时分期已经偏晚,早期根治治疗效果确切,CEA检查有助于判断预后.Objective To investigate the clinical characteristics and prognosisof young patients with lung cancer. Methods From January 2008 to September 2013, 81cases of young lung cancer were selected for retrospectively analysis aboutclinical characteristicsand prognostic factors. Results Twenty one cases of lung cancer had been founded byphysical examination. Sixty patients had clinical symptoms, and coughaccounted for 78.3% , chest pain 38.3% , shortness of breath 13.3% , blood in sputum 11.7%. There were 23 cases in stage Ⅰ, accounting for 28.3% , 3 cases in stage II , accounting for 3.7% , 14 cases in stageⅢ , accounting for 17.4% , 41 cases in stage IV, accounting for 50.6%. Lymph node metastasis accounted for 39.5% , pericardial and pleuralmetastasis accounted for 30.9% , tung metastasis accounted for 16.5% ,and bone metastasis accounted for 12.3%. CEA average value was 25.0 ±8.2μg/ml. The median survival of P values was more than 0.05. There was nosignificant difference in survival of P value between smokers group and non - smokers group, but there were significant difference among sex,with or without lymph node metastasis, stage Ⅰ～Ⅱ、Ⅲ、Ⅳ radical surgery or palliative care, adenocarcinoma or Non - adenocarcinoma, CEA normal or elevated group, non - clinical symptom group ormedical symptoms group. One - year survival rateis 56.2% , and 3 - year survival rate is I5.4%. Conclusion Young people withlung cancer had no specific clinicalmanifestations, however theirprognosis is very poor because of high degree of malignancy. They were proneto metastasis in cluding lymph nodes, pleural, pericardial, lung and othertransfers, and no correlation with smoking. Symptomaticoccurrenceindicatedpoorprognosis and partial late stages, and there wasexact effect of early radical treatment, CEA examination also can help determine prognosis.

关 键 词：青年 肺癌 临床特点 预后因素 

分 类 号：R734[医药卫生—肿瘤]