认知事件相关诱发电位P300的研究进展  

Research progress of cognitive event related potential P300

作　　者：叶斌[1] 

机构地区：[1]安徽省蚌埠市第三人民医院神经内科,233000

出　　处：《中华解剖与临床杂志》2014年第2期170-173,共4页Chinese Journal of Anatomy and Clinics

摘　　要：目的 探讨认知事件相关诱发电位（ERP）P300的研究进展。方法 在万方数据、Pubmed等数据库查阅与认知ERP P300研究相关的文献,进行汇总分析。结果 ERP P300反映了大脑认知的加工过程,可对痴呆、脑血管疾病、脑外伤、癫痫、精神疾病等多种疾病进行早期认知减退的检测、认知功能和损害程度的评估以及认知功能的定量分析,具有较广泛的临床应用价值。但P300的临床应用存在没有业内公认的评定标准值、实际检测中影响因素较多等问题,其具体机制及相关问题的解决还有待于进一步更深入地探讨。结论 P300可以检测大脑神经细胞的动态认知过程,具有可靠、有效、客观、无创伤等特点,是其他脑影像技术所不能取代的一种检测方法。未来还需在P300及其亚波的产生定位及临床诊断的统一化标准化等方面做进一步的深入探索和研究。Objective To investigate the research progress of cognitive event-related potential（ERP） P300. Methods Literature data of the cognitive ERP P300 from Wanfang database, Pubmed and other databases were collected and analyzed. Results Brain cognitive processes is reflected in the P300 ERP. ERP-P300 can be used for early detection of cognitive decline of many diseases, the extent of the damage assessment of cognitive function and cognitive function in quantitative analysis, which include dementia, cerebrovascular disease, traumatic brain injury, epilepsy, mental illness, etc. It has a wider range of clinical applications. However, the clinical applications of the P300 have problems： no recognized evaluation criteria value, many factors of the actual impact on the detection and so on. The specific mechanisms and related issues need to be further discussed. Conclusions P300 can be used to detect dynamic cognitive processes of nerve cells. It is characterized by reliable, efficient, objective, non-invasive and so on. It is a method of detecting that other brain imaging techniques can not be replaced. In the future, further researches are needed in the production and positioning of P300 and P300′s Copiapo, unified standardized clinical diagnosis and so on.

关 键 词：认知 事件相关诱发电位 P300 

分 类 号：R741.044[医药卫生—神经病学与精神病学]