非霍奇金氏淋巴瘤患者血清β_2-微球蛋白检测对预后的价值  

Prognostic Value of Serumβ_2- Microglobulin Level in Patients with Non- Hodgkin′ s Lymphoma

作　　者：夏忠军[1] 黄仁魏[1] 吴祥元[1] 林桂真[1] 张力[2] 管忠震[2] 

机构地区：[1]中山医科大学附属第三医院血液科,广东广510630 [2]中山医科大学肿瘤防治中心内科,广东广州510060

出　　处：《癌症》2001年第4期406-408,共3页Chinese Journal of Cancer

摘　　要：目的：探讨血清β_2-微球蛋白 (β_2- microglobulin,β_2- MG)水平对非霍奇金氏淋巴瘤（ non- Hodgkin s lymphoma,NHL）预后估计的意义，以及与 Ann Arbor分期、组织学分型的关系。方法：采用放射免疫分析法对在我科就诊的 75例初治 NHL患者外周血血清中的β_2- MG水平进行测定。结果： 75例初治 NHL患者的β_2- MG值高于正常者达 52％。在确诊时β_2- MG水平的高低与 Ann Arbor分期相一致，各组间有显著的差异（ P< 0.01）。根据 IPI(international prognostic index,IPI)指数所区分的 NHL恶性度高低与β_2- MG血浆中的水平有明确的相关关系，确诊时β_2- MG的水平与化疗效果有明确的相关关系，β_2- MG正常组化疗有效率达 87.2％，其中 CR率为 61.5％， PR率为 25.6％；β_2- MG升高组有效率为 75.0％，其中 CR仅为 50.0％； PR 25.0％，两者比较有显著的统计学差异（ P< 0.05），两组的 5年总生存率有明显的统计学差异（ 63 0％ vs 27.8％ ,P< 0.05）。结论：β_2- MG可做为初诊时一独立的血清学预后指标来预测 NHL患者对化疗的反应和生存情况，β_2- MG升高者对化疗的有效率低且预后差。Objective: This study was designed to investigate the prognostic value of serumβ_2- micorglobulin(β_2- MG) level in non- Hodgkin s lymphoma(NHL) patients and its correlation with Ann Arber staging system and the pathological type. Method: Serumβ_2- MG levels in 75 de novo NHL patients were measured by radioimmunoassay. Results: Theβ_2- MG level in 75 NHL patients was higher than that in nomal control level in 52％ of the patients and correlated with the Ann Arber stage. There was significant difference between two groups (P< 0.01). The international prognostic index (IPI) and the response rate to chemotherapy were also correlated with theβ_2- MG level in serum. The response rate, the complete response, and partial response were 87.2％ ,61.5％， and 25.6％ in normal serumβ_2- MG group, while in the highβ_2- MG group they were only 75.0％ , 50.0％ , and 25.0％ , respectively, which were significantly different between the two groups (P< 0.05). The difference of 5- year survival between the two groups was significant (64.1％ vs 27.8％ , P< 0.05) and favorable in normalβ_2- MG group. Conclusion:β_2- MG level in serum is an independent prognostic factor in de novo NHL, and the patients with abnormalβ_2- MG level in serum have a unfavorable prognosis.

关 键 词：Β2-微球蛋白 非霍奇金氏淋巴瘤 预后 

分 类 号：R733.1[医药卫生—肿瘤]