中心静脉导管引流并心包内化疗治疗肺癌致心包积液  

Pericardial Effusion in Patients with Lung Cancer Treated with Safe- Dwel Plus Drain and Intrapericardial Chemotherapy

作　　者：高峰[1] 李秋艳[1] 孙建国[1] 付守忠[1] 王俊峰[1] 

机构地区：[1]黑龙江省鸡西矿务局总医院肿瘤科,黑龙江鸡西158100

出　　处：《癌症》2001年第4期429-430,共2页Chinese Journal of Cancer

摘　　要：目的：探讨控制肺癌所致恶性心包积液的有效治疗方式。方法： 16例肺癌致恶性心包积液患者，经中心静脉导管引净积液后心包内注入顺铂、足叶乙甙，再持续引流积液至每日引流量少于 50 ml后撤管。结果：完全缓解 13例、部分缓解 2例，有效率 93.8％；全组中位生存 6.5个月，全组死于心包积液未控或复发 2例。全组出现胃肠道反应 11例，骨髓抑制 3例，经对症处理均缓解。结论：中心静脉导管引流心包积液并心包腔内注入顺铂、足叶乙甙是治疗肺癌致恶性心包积液较理想的治疗方法。Objective： The aim of this study was to approach an efficient way in the treatment of pericardial effusion of lung cancer. Methods： Sixteen patients with pericardial effusion of lung cancer are drained with Safe- Dwel Tlus, then cisplatin and etoposide were injected into the pericardial cavity, and the draining continually effusion to less 50 ml per day. Results： The total effective rate was 93.8％ with 13 cases of complete response rate and 2 cases of partial response rate. The median survival time was 6.5 months. 2 cases died from the relapse of pericardial effusion or no effect. Eleven cases had gastrointestinal tract reaction, and 3 cases with repression of bone marrow. However all side effects were controlled by treatment. Conclusion： Safe- Dwel Tlus drain with injecting cisplatin and etoposide into pericardial cavity may be a better way to control malignant pericardial effusion of lung cancer.

关 键 词：继发性恶性心包积液 肺肿瘤 中心静脉导管 药物治疗 

分 类 号：R734.2[医药卫生—肿瘤] R732.1[医药卫生—临床医学]