急性白血病与可溶性肿瘤坏死因子受体的相关性研究  

Relationship between acute leukemia and soluble tumot hecrosis factor

作　　者：程玉芝[1] 李振娥[1] 班博[1] 董中霞[1] 戴建华[1] 

机构地区：[1]济宁医学院附属医院,山东济宁272029

出　　处：《山东医药》2001年第6期15-16,共2页Shandong Medical Journal

基　　金：山东省济宁市科委科研基金资助项目!(NO2 0 0 0 2 7)

摘　　要：应用 EL ISA法检测了 6 0例急性白血病 (AL )患者及 36例正常对照者的血清可溶性肿瘤坏死因子受体 (s TNFR- 和 s TNFR- )及血清肿瘤坏死因子 α(TNFα)。结果显示 ,1初发未治组及复发难治组血清 s TN-FR- 和 s TNFR- 浓度均明显高于正常对照组 (P<0 .0 1) ;骨髓缓解组血清 s TNFR浓度与正常对照组无明显差异。 AL患者与对照组比较血清 TNF-α水平明显增高 (P<0 .0 0 1) ;2血清 TNF-α水平与 s TNFR- 呈显著性正相关 (r=0 .6 84,P<0 .0 1) ,与 s TNFR- 无相关性 (r=0 .310 ,P>0 .0 5 ) ;血清 s TNFR- 、 s TNFR- 水平与外周血幼稚细胞数呈显著正相关 (r=0 .748,P<0 .0 0 1;r=0 .384,P<0 .0 5 ) ;3 30例初发未治者治疗前血清 s TNFR- <0 .89μg/ L、 s TNFR- <1.43μg/ L者的 BMR率 (70 .0 %、 6 1.5 % )明显高于 s TNFR- ≥0 .89μg/ L、s TNFR- ≥ 1.43μg/ L 者的 BMR率 (χ2 =10 .80 ,P<0 .0 1;χ2 =8.2 1,P<0 .0 1) ;4采用多因素非条件 L ogistic回归分析 ,发现仅血清 s TNFR- <2 .0μg/ L及外周血 WBC<10× 10 9/ L对骨髓缓解率有显著影响(OR=0 .387,P=0 .0 0 2 5 ;OR=0 .5 2 49,P=0 .0 0 87)。因此认为 ,AL患者血清 s TNFR水平与白血病细胞、病程和化疗的反应相关 ,血清 s TNFR水平?Serum tumor necrosis factor(TNFα),serum soluble tumor necrosis factor receptor Ⅰ(sTNFR Ⅰ)and soluble tumor necrosis factor receptor(sTNFR Ⅱ)were detected with enzyme link immunosorbent assay in 60 acute leukemia(AL) cases and 36 health subjects The results showed:①Serum levels of sTNFR Ⅰ and sTNFR Ⅱ in 30 untrearted AL patients and 14 relapsed/refractory AL patients were significantly higher than those in controls(P<0 001and P<0 001),but in 16 bone marrow remission(BMR)AL patients its were not different from those in controls(P>0 05) Serum levels of TNFα in AL patients were significantly higher than those in controls(P<0 001) ②There were remarkably positive relationship between serum TNFα and sTNFR Ⅰ levels(r=0 684,P<0 01),two sTNFRs and peripheral blood blasts(r=0 748,P<0 001;r=0 384,P<0 05) ③The BMR rate was higher in those serum sTNFR Ⅰ<0 89μg/L than that in those sTNFR Ⅰ≥0 89μg/L(χ 2=10 80,P< 0 01). ④Logistic regression analysis showed that serum sTNFR Ⅰ<2 0μg/L and peripheral blood blasts<10×10 9/L were associated with BMR Those indicated the enhanced serum sTNFRs levels in AL might have relation to leukemic cells,course and drug response and the serum sTNFRs were an index of predicting prognosis

关 键 词：急性白血病 可溶性肿瘤坏死因子受体 相关性 

分 类 号：R733.71[医药卫生—肿瘤]