多棘海盘车AST抗氧化作用研究  

Study on Antioxidation of Succinic Di-(3β-hydroxyandrost-5-en-17-one) Ester

作　　者：高玫梅[1] 刘燕[1] 燕启江[1] 许东晖[2] 许实波[2] 

机构地区：[1]广州医学院神经科学研究所,广州510182 [2]中山大学生命科学学院药学系,广州510275

出　　处：《现代临床医学生物工程学杂志》2001年第1期7-8,共2页Journal of Modern Clinical Medical Bioengineering

基　　金：国家"九五"重点科技攻关项目! (编号 :96 -C0 2 - 0 4 - 0 1 )

摘　　要：目的　以兔和大鼠心肌及肝组织匀浆为材料 ,研究一种从多棘海盘车 (Asteriasamurensis)中提取得到的活性物质经结构改造和修饰得到的丁二酸二 - ( 3β -羟基雄甾 5 -烯 - 17-酮 )酯新化合物 (代号AST)抗脂质过氧化作用 .方法　在体外组织匀浆自发或Cys+FeSO4 激发脂质过氧化模型上 ,以丙二醛 (MDA)产生作为过氧化程度指标 .结果　AST在体外能抑制正常大鼠和兔心肌及肝匀浆过氧化脂质生成 ,并能对抗半胱氨酸和硫酸亚铁所致过氧化脂质生成增加 .Objective To study antioxidation of Di-(3β-hydroxyandrost-5-en-17-one) ester (AST), a new compound which was structure derivated from active substance from Asterias amurensis. Methods Samples of tissues homogenates were pretreated with AST, then, addition of FeSO 4+Cysteine(Cys) or not, the generation of malondialdehyde(MDA) was examined. Results The production of lipid peroxides in normal cardiac, liver homogenate of rat and rabbit,elevation of production of lipid peroxides induced by and FeSO 4+Cys in. homogenate Conclusions AST have the effect of antilipid peroxidation on rats and rabbits' cardiac and liver tissue.

关 键 词：丁二酸二-(3β-羟基雄甾5-烯-17-酮)酯 组织匀浆 脂质过氧化 多棘海盘车 AST 海洋药物 

分 类 号：R285.5[医药卫生—中药学]