牛磺酸对高碘仔鼠脑发育和学习能力的影响  

Effects of taurine on brain development and learning ability in filial mice fed with high iodine

作　　者：许丽辉 尹桂山 朱惠民[1] 李英华[1] 王桂香[2] 孙素菊[3] 齐锦生[2] 

机构地区：[1]河北医科大学环境卫生学教研室,石家庄市050017 [2]河北医科大学生物化学教研室,石家庄市050017 [3]河北医科大学劳动卫生学教研室,石家庄市050017

出　　处：《中华预防医学杂志》2001年第2期114-116,共3页Chinese Journal of Preventive Medicine

基　　金：河北省自然科学基金资助 !(3 982 85 )

摘　　要：目的　探讨牛磺酸对高碘仔鼠脑发育和智力的影响。方法　将动物随机分为 3组 :适碘组、高碘组、高碘 +0 6 %牛磺酸组 (简称牛磺酸组 )。各组亲代小鼠饲养 3个月后雌雄交配 ,测定各组 30日龄仔鼠的学习记忆能力及脑组织相关生化指标。结果　高碘组 30日龄仔鼠脑蛋白质和DNA含量下降 ,牛碘酸组与适碘组差异无显著性 ;高碘组 30日龄仔鼠脑海马组织乙酰胆碱酯酶活性比适碘组和牛磺酸组明显升高 ,乙酰胆碱含量下降。与适碘组相比 ,牛碘酸组乙酰胆碱酯酶活性无统计学差异 ,而乙酰胆碱含量上升。Objective To observe the effects of taurine on brain development and learning ability in filial mice fed with high iodine. Methods Mice were divided into three groups, the first one fed with adequate dose of iodine, the second with high dose iodine, and the third with high dose iodine plus 0 6% taurine All the male and female mice were mated three months after treatment Relevant biochemical indicators in the brain tissues and their memory and learning ability were measured for their offsprings with 30 days old in the three groups. Results Brain contents of protein and DNA reduced in the high dose iodine group, and there was no significant difference in them between groups with taurine and adequate dose iodine 30 days after their birth Activity of acetylcholine esterase (ACHE) increased and content of acetylcholine decreased in the hippocampus of filial mice at age of 30 days with high dose iodine Content of acetylcholine increased in the filial mice with high dose iodine plus taurine than that with adequate dose iodine, but there was no statistically significant difference in ACHE between them. Conclusion Taurine could antagonize disturbance of brain development in filial mice caused by high dose iodine

关 键 词：牛磺酸 高碘 脑发育障碍 学习能力 仔鼠 

分 类 号：R965[医药卫生—药理学]