大鼠实验性胃溃疡自愈期间胰岛β-EP、5-HT、5-HTR细胞的免疫组织化学研究  

THE IMMUNOHISTOCHEMICAL STUDY ON β-EP,5-HT,5-HTR CELLS IN PANCREATIC ISLETS OF RATS DURING EXPERIMENTAL GASTRIC ULCER

作　　者：吴靖芳[1] 周济远[1] 王建伟[1] 任君旭[1] 张耕[1] 

机构地区：[1]张家口医学院组织学胚胎学教研室,张家口075029

出　　处：《解剖学报》2001年第2期190-192,T020,共4页Acta Anatomica Sinica

基　　金：河北省教委科研资金资助! (98115 )

摘　　要：目的　探讨大鼠实验性胃溃疡自愈期间 ,胰岛 β-内啡肽 (β- EP)、5 -羟色胺 (5 - HT)、5 -羟色胺受体蛋白(5 - HTR)免疫反应细胞的变化。　方法　免疫组织化学技术。　结果　溃疡术后 4d、10 d胰岛 β- EP、5 - HT、5 - HTR细胞面数密度增高。β- EP、5 - HT细胞于 4d达高峰 ;5 - HTR细胞于 10 d达高峰。邻片示 :部分 β- EP、5 - HT及 5 - HTR阳性物质分别位于 A或 B细胞。　结论　胰岛 β- EP、5 - HT、5 - HTR细胞可能间接或直接参与大鼠实验性胃溃疡修复的调节。Objective Studies on the changes of β EP, 5-HT, 5-HTR immunoreactive cells in pancreatic islets during experimental gastric ulcer. Methods The immunohistochemical technique was used. Results The numerical densities on area of β EP, 5-HT, 5-HTR cells in experimental gastric ulcer group were higher than control group on the 4day,10day after operation.The peak of the numerical densities on area of β EP and 5-HT cells appeared on the 4th day, while the peak of 5-HTR cells as on the 10th day. Part of β EP, 5-HT,5-HTR immunoreactive material were located in A or B cells neighbourly section. Conclusion The present work proved that the β EP, 5-HT,5-HTR cells of pancreatic islets were directly or indirectly participated in the regulation balance of endocrine during the self-healing process of the experimental gastric ulcer and here we provided morphological evidence.;

关 键 词：β-内啡肽 5-羟色胺 5-羟色胺受体 胰岛 实验性胃溃疡 大鼠 

分 类 号：R573.102[医药卫生—消化系统]