中期和晚期乳腺单纯癌癌细胞形态结构的体视学分析  

The stereologic analysis of morphological structure in mid stage and late stage of the simple carcinoma of breast

作　　者：刘美玉[1] 陈平[1] 李维波[1] 刘爱武[2] 钱纬[2] 张华献[3] 

机构地区：[1]昆明医学院物理教研室,云南昆明650031 [2]昆明医学院电镜室,云南昆明650031 [3]云南省肿瘤医院,云南昆明650031

出　　处：《中国医学物理学杂志》2001年第1期40-41,共2页Chinese Journal of Medical Physics

基　　金：云南省教委应用基础研究基金资助项目

摘　　要：用体视学方法对中期、晚期乳腺单纯癌（各20例）的细胞、细胞核、核仁的17个形态参数进行测试分析,发现癌中期组、癌晚期组、正常组之间相互比较,核面密度、核比表面,核平均体积、核平均截面积,核平均周长、核仁平均周长等6个参数有显著和高度显著差异,提示了癌症病人到了晚期细胞核被膜面积明显减小,核体积膨胀更厉害,核仁平均周长都明显减小,晚期癌症病人的预后更差。In this article,stereologic method was applied in analyzing 17 morphological parametera of cell, nucleus and nucleo-lus in 20 cases of mid stage and late stage of the simple carcinoma of breast (the stylebooks of EM photos were 320). We analyzed the difference of each sort of cell with T test and Q test. Compared with the normal cells, the cancer cells of mid stage were found obviously not only decreased in their nucleus surface density Svn and nucleus contrast surface density Sn but also increased in their nucleus average section An and nucleus average perimeter Bn. Compared with the cancer cells of the mid stage the cancer cell of the late stage were found obviously increased in their nucleus average volume Vn and Bn. Compared with the normal cells, the cancer cells of the late stage were found obviously not only decreased in their Svn and Sn but also increased in their Vn, An, Bn and nucleolus average perimeter Bu.

关 键 词：体视学 细胞 细胞核 核仁 乳腺单纯癌 

分 类 号：R737.9[医药卫生—肿瘤]