曲唑酮和舒乐安定治疗抑郁症患者睡眠障碍多中心开放研究  

Multicentric and open study on the effect of trazodone and surazepam on insomnia of depression patients

作　　者：陶明毅[1] 笪志民[1] 江开达[2] 顾牛范[2] 

机构地区：[1]上海市精神卫生中心,上海200030 [2]上海医科大学

出　　处：《现代康复》2001年第3期28-29,共2页Modern Rehabilitation

摘　　要：目的验证曲唑酮对抑郁症伴失眠患者的安眠作用。方法 35例单相抑郁发作或双相情感障碍抑郁发作伴有明显失眠者，汉密尔顿抑郁量表（ HAMD）得分≥ 24分完成 4周治疗。结果治疗前后两组病人总睡眠时间、早醒延迟时间、夜间觉醒次数与治疗前相比有明显改善 (P< 0.05)。 HAMD睡眠因子分两组治疗前后明显改善（ P< 0.05或 P< 0.01）。曲唑酮能显著改善深度睡眠。除口干、便秘发生频率较高外 (P< 0.05)，曲唑酮其它副作用发生频率不高于舒乐安定。结论曲唑酮的安眠作用值得推荐应用。： Objective To investigate the hypnotic effect of trazodone on depression patients with insomnia. Method 35 cases with single episode of depression or depressive phase of bipolar affective disorder accompanied by apparent insomnia and Hamilton depression scale( HAMD) score≥ 24 accepted four－ week treatment with trazodone. Result At the end of trial, total sleeping time, postponement of early awakening and frequencies of waking up in sleeping time had significantly improved than those of before the treatment(P< 0.05) in both groups. Sleeping factors of HAMD were markedly improved, too(P< 0.05 or P< 0.01). The other benefit of trazodone focused on improving the deep sleeping. The side effects of trazodone developed no more frequenly than those of surazepam except for dry mouth and constipation(P< 0.05). Conclusion It was worth applying the hypnotic effect of trazodone for the improvement of depression patients with insomnia.

关 键 词：抑郁症 失眠 曲唑酮 催眠作用 治疗 

分 类 号：R749.405[医药卫生—神经病学与精神病学]