3,6-二取代-5,6-二氢-1,2,4-均三唑并[3,4-b]-1,3,4-噻二唑的合成及抗菌活性  

SYNTHESIS AND ANTIBACTERIAL ACTIVITIES OF 3,6-DISUBSTITUTED- 5,6-DIHYDROGEN-1,2,4- S -TRIAZOLO-[3,4-b]-1,3,4-THIADIAZOLES

作　　者：史海健[1] 王忠义[2] 史好新[2] 

机构地区：[1]南京大学化学系,江苏南京210093 [2]安徽师范大学化学系

出　　处：《药学学报》2001年第4期310-312,共3页Acta Pharmaceutica Sinica

基　　金：安徽省自然科学基金资助课题 !(110 0 2 1)

摘　　要：AIM To synthesize a series of new fused heterocyclic compounds containing 1,2,4-triazole and 1,3,4-thiadiazole rings. METHODS and RESULTS Nine new fused heterocyclic compounds have been synthesized by the reaction of 3-p-nitrophenoxymethyl-4-amino-5-mercapto-1,2,4-triazole with aromatic aldehydes in the presence of acid. The reaction conditions for the synthesis have been investigated. The structures of the synthesized compounds were confirmed by elemental analysis, IR, 1HNMR and MS. All of the compounds were screened for their biological activities. CONCLUSION The results show that some compounds (2c, 2d, 2e, 2f) showed strong antibacterial activities.AIM To synthesize a series of new fused heterocyclic compounds containing 1,2,4-triazole and 1,3,4-thiadiazole rings. METHODS and RESULTS Nine new fused heterocyclic compounds have been synthesized by the reaction of 3-p-nitrophenoxymethyl-4-amino-5-mercapto-1,2,4-triazole with aromatic aldehydes in the presence of acid. The reaction conditions for the synthesis have been investigated. The structures of the synthesized compounds were confirmed by elemental analysis, IR, 1HNMR and MS. All of the compounds were screened for their biological activities. CONCLUSION The results show that some compounds (2c, 2d, 2e, 2f) showed strong antibacterial activities.

关 键 词：均三唑 抗菌活性 合成 3 6-二取代-5 6-二氢-1 2 4-均三唑并[3 4-b]-1 3 4-噻二唑 

分 类 号：TQ463.53[化学工程—制药化工]