人体慢性肝病和肝癌的定量病理诊断研究(Ⅰ.慢性肝病及肝癌的形态定量分析)  

Quantitative Pathologic Diagnostic Studies on the Human Chronic Liver Diseases and Hepatocarcinoma (I.Morphometric Analysis of the Human Chronic Liver Diseases and Hepatocarcinoma)

作　　者：章宗籍[1] 申丽娟[1] 欧阳明[2] 黄润[1] 张华献[1] 王红[3] 

机构地区：[1]昆明医学院病理学教研室,昆明650031 [2]云南大学实验中心图象分析室,昆明650091 [3]昆明医学院寄生虫学教研室,昆明650031

出　　处：《昆明医学院学报》2001年第1期5-8,共4页Journal of Kunming Medical College

基　　金：云南省教委青年基金!资助项目 (90 40 0 33)

摘　　要：利用自动化图象分析技术对轻度慢性肝炎、重度慢性肝炎、小结节肝硬变、大结节肝硬变、癌周肝硬变和肝细胞癌等 6种慢性肝病及正常对照共 6 7例样本 ,分别作了 13项参数的形态定量研究和肝细胞DNA含量测定分析 .结果 :结合两种形态定量方法 ,除重度慢性肝炎和大结节肝硬变间差异无显著性外 ,其余各组间均有显著性差异 ,提示肝细胞形态及DNA含量参数对上述慢性肝病具有较好的诊断和鉴别诊断价值 .The nuclear DNA contents and 13 morphometric parameters of hepatocytes in 67 humancases were measured by using an automated image analyser in normal liver, mild chronic hepatitis, severe chronic hepatitis, micronodular cirrhosis, macronodular cirrhosis, pericarcinoma cirrhosis and hepatocellular carcinoma. The results showed that the difference were statistically significant among all the groups but between the group of severe chronic hepatitis and macro nodular cirrhosis to combine using two methods of morphometry. It may be significant for diagnosis and differential diagnosis of various chronic liver diseases by determine morphometric parameters and the nuclear DNA contents of hepatocytes.

关 键 词：肝肿瘤 肝细胞癌 肝硬变 肝炎 形态计量 DNA倍体 

分 类 号：R735.7[医药卫生—肿瘤] R575[医药卫生—临床医学]