神经生长因子对大鼠脑缺血再灌注海马神经细胞损伤的影响  

Effect of Nerve Growth Factor on the Neuronal Injury in the Hippocampus Following Cerebral Ischemia and Reperfusion in Rats

作　　者：施宁华[1] 许浒[1] 张志坚[1] 王卉放[1] 卢步峰[1] 戴树宏[1] 

机构地区：[1]镇江医学院医学系,212001

出　　处：《中国临床神经科学》2001年第1期13-15,共3页Chinese Journal of Clinical Neurosciences

基　　金：江苏省教委自然科学基金资助 (941 70 )

摘　　要：目的 :观察神经生长因子 (NGF)对脑缺血再灌注后海马CA1区神经细胞损伤的影响。方法 :采用大鼠脑缺血再灌注模型 ,在光镜和透射电镜下观察NGF治疗组和缺血再灌组动物脑缺血 3 0min再灌注 2 4h和 72h时海马组织学及超微结构的改变。结果 :在缺血 3 0min再灌注 2 4h和 72h时 ,NGF治疗组海马CA1区神经细胞的结构损伤与缺血再灌组比较显著减轻 ;NGF可以减轻海马迟发性神经细胞死亡 (DND)性损伤。结论Aim:To observe the effects of nerve growth factor (NGF) on the neuronal cell injury in the hippocampal CA 1 sector following cerebral ischemia reperfusion in rats. Methods:With cerebral ischemia reperfusion rat model,using light microscopy and transmission electron microscopy, the changes of histology and ultrastructure of the hippocampus were observed at reperfusion for 24h and 72h after 30 min of ischemia in groups with and without treatment with NGF. Results:The structural damage of hippocampal CA 1 neurons reduced markedly in the NGF treated group than that in the control group during reperfusion for 24h and 72h after 30 min of ischemia. NGF could ease the delayed neuron death (DND) after ischemia reperfusion. Conclusion:NGF has a protective effect on neuronal injury induced by reperfusion postischemia.

关 键 词：脑缺血 再灌注损伤 神经生长因子 海马 神经细胞 大鼠 

分 类 号：R743.310.2[医药卫生—神经病学与精神病学]