冬虫夏草和中国拟青霉对小鼠免疫性肝损伤的保护作用  

The protective effects of CS and CN80 2 against the immunological liver injury in mice

作　　者：曾宪可[1] 唐玉[1] 袁盛榕[1] 

机构地区：[1]首都医科大学药理教研室,北京100054

出　　处：《中国药学杂志》2001年第3期161-164,共4页Chinese Pharmaceutical Journal

摘　　要：目的　研究冬虫夏草 (CS)和中国拟青霉 (CN80 2 )对小鼠免疫性肝损伤的保护作用。方法　小鼠分别尾静脉注射BCG +LPS造模 ,当日ig给予CS ,CN80 2 ,每天 1次 ,连续 10d。 10d后 ,检测其血清ALT和AST活性及肝脾重量指数 ,并用硫代巴比妥酸法测定血清与肝组织中LPO含量 ,用L92 9细胞为靶细胞检测血清中TNFα的活性。结果　CS ,CN80 2 (1.0g·kg-1·d-1,10d)抑制小鼠血清ALT ,AST活性 ,降低其血清与肝组织中LPO含量 ,并减轻其增大的肝、脾重量指数 ,降低血清中的TNF水平。结论　CS ,CN80 2预防性给药对BCGOBJECTIVE To study the protective effects of Cordyceps sinensis (Berk).Sacc (CS) and Paecilomyceps sinensis sp.nov(CN80 2) against the immunological liver injury in mice induced by BCG and LPS.METHODS LPS was injected via the tail vein into mice pretreated with BCG.The activities of serum ALT and AST and TNFα, the weighing indexes of liver and spleen,the levels of LPO in serum and hepatic tissues were tested respectively.RESULTS CS and CN80 2 at the dose of 1.0 g·kg -1 ·d -1 for consecutively 10 days,remarkably inhibited the activities of serum ALT and AST,and decreased the liver and spleen enlarged index and LPO levels in serum and hepatic tissues in mice ,and reduced the serum TNFα level.CONCLUSION Pretreatment with CN and CN80 2 moderately prevented the liver damage induced by BCG+LPS in mice.

关 键 词：冬虫夏草 中国拟青霉 免疫性肝损伤 卡介苗 脂多糖 小鼠 

分 类 号：R575[医药卫生—消化系统] R967[医药卫生—内科学]