微电极导向VL核和PVP核联合毁损治疗帕金森病  

Microelectrode stereotactic guided combined thalamotomy and posterventral pallidotomy for Parkinson's disease

作　　者：张世忠[1,2] 徐如祥[1,2] 张旺明[1,2] 李勇杰 

机构地区：[1]第一军医大学珠江医院神经外科 [2]宣武医院功能神经外科中心

出　　处：《功能性和立体定向神经外科杂志》1999年第2期7-11,共5页

摘　　要：目的：对震颤、僵硬及运动迟缓帕金森病（ＰＤ）患者的立体定向手术方法学进行探讨。方法：应用微电极导向技术，对４３例ＰＤ患者，同侧丘脑腹外侧核（Ｖｉｍ／Ｖｏｐ）及苍白球腹后部（ＰＶＰ）进行联合毁损术。结果：４３例ＰＤ患者的肢体震颤、僵硬及运动迟缓均得到明显改善，术前术后ＭｏｔｏｒＵＰＤＲＳ积分，开状态及关状态均显著改善（Ｐ＜０．０１），无永久并发症。结论：应用微电极导向立体定向技术对伴有肢体震颤、强直及运动迟缓的ＰＤ患者，行同侧Ｖｉｍ核和ＰＶＰ核联合毁损手术，能全面改善ＰＤ患者的症状，是一种安全有效的手术方法。Objective:To probe the stereotactic operative therapy for Parkinson's disease with tremor,rigidity and bradykineia.Methods:With the help of microelectrode guided technique,underwent ipsilateral thalamotomy and pallidotomy for 43 parkinsonian patients.Reults:Tremor,rigidity and bradykinesia of all 43 patients are alleviated distinctly.Preoperative and postoperative UPDRS score,'on' and 'off' condition are improved significantly.No permanent operative complications.Conclusion:For parkinsonian patients with tremer,rigidity and badykinesia,the mincroeletrode gutients with tremor,rigiolity and bradykinesia,the microeletrode guided combined ipsilteral Vim/Vop thalamotomy and posterbentral pallidotomy is a good complementary for thalatomy's ineffective reliable to tremor.The excellent combination of thalamotomy and pallidotomy does not increase the danger of operation and can alleviate symptoms of Parkinson's disease in an all-around.It's a safe and effectve surgical therapy.

关 键 词：帕金森病 微电极记录 立体定向术 丘脑腹外侧核毁损术 

分 类 号：R742.505[医药卫生—神经病学与精神病学]