缺血性脑血管病患者血清α_2-巨球蛋白的观察  

OBSERVATION OF α_2-MACROGLOBULIN IN PATIENTS WITH ISCHEMIC CEREBROVASCULAR DISAESE

作　　者：张晨[1] 韩仲岩[1] 于竹英 杨颉[2] 翁维权[2] 

机构地区：[1]青岛医学院附院神经科 [2]青岛医学院附院血液病室

出　　处：《青岛医学院学报》1990年第1期12-14,共3页Acta Academiae Medicinae Qingdao Universitatis

摘　　要：缺血性脑血管病患者184例,男110例,女74例,年龄37～74岁,平均56.42±9.37岁.用单向免疫扩散法对其血清α_2-巨球蛋白进行了测定,结果发现,脑血栓形成急性期和恢复期,α_2-巨球蛋白与对照组相比均有显著性差异(P<0.001);伴糖尿病脑血栓形成者血清α_2-巨球蛋白明显高于不伴糖尿病者(P<0.001).提示α_2-巨球蛋白在维持凝血与纤溶的平衡中具有重要作用.Determination of α_2-macroglobulin were carried out in 184 patients, including 110 males and 74 females, aged 37～74 years,averaging 56.42±9.37, of whom 41 had cerebral atherosclerosis, 17 transient ischemic attacks, 56 cerebral thrombosis, 31 cerebral thrombosis and diabetes, and 39 cerebral thrombosis during convalescence. The levels of α_2-macroglobulin in the sera of the patients with thrombosis, cerebral thrombosis and diabetes, or cerebral thrombosis during convalescence,were found significantly higher than those in the control group (P<0.001). There were no great changes in patients with cerebral atherosclerosis and those with transient ischemic attacks(P>0.05).It is suggested that the elevated α_2-macroglobulin might show the hupercoagulative state of the blood.

关 键 词：脑缺血 脑血栓形成 Α2-巨球蛋白 糖尿病 血清诊断 

分 类 号：R743.306[医药卫生—神经病学与精神病学] R587.204[医药卫生—临床医学]