癫痫患儿免疫状态与疗效关系的探讨  

A STUDY OF RELATIONSHIP BETWEEN CURATIVE EFFECT AND IMMUNE STATE IN EPILEPSY CHILDREN

作　　者：韩迎春[1] 庞秀英[1] 程建国[2] 解学孔[2] 张增光[2] 

机构地区：[1]青岛医学院附院小儿内科 [2]青岛医学院附院神经病学研究室

出　　处：《青岛医学院学报》1990年第1期36-39,共4页Acta Academiae Medicinae Qingdao Universitatis

摘　　要：通过比较30例经抗癫痫治疗无效或效差患儿与59例显效患儿的8项免疫学指标发现,治疗无效或效差组血清IgG,IgM,IgA(女性)平均含量及E玫瑰花环形成率均显著低于显效组(P<0.05),补体C_3水平显著高于显效组(P<0.05).上述变化与患儿年龄、临床发作类型、病程及疗程等因素无关.从而提示免疫功能低下不仅是癫痫患者自稳机制紊乱的表现,而且也是影响疗效的重要因素,改善免疫功能可能是提高抗癫痫治疗效果的有效途径之一.In order to explore the relationship between curative effect and immune state in epilpsy children, we conpared 8 immunolgical indices of 30 cases of epilepsy children who failed to response to therapy with those of 59 cases of epilepsy children who presented obvious curative effect. It was found that in the former group, the mean contents of IgG, IgM, IgA (in female)and rate of erythrocyte rosette formation decreased significantly (P<0.05) ,while content of complement C_3 increased significantly (P<0.01).The data suggest that inadequacy of immune function might be a cause of failing to response to the therapy, and improving immune function might be an effective way to raise curative effect of epilensv.

关 键 词：癫痫 免疫球蛋白类 儿童 疗效 免疫功能 

分 类 号：R742.1[医药卫生—神经病学与精神病学]