白细胞介素-1受体拮抗剂(IL-1ra)治疗角膜烧伤实验研究  

Study on Treatment of Corneal Burn with Interleukin-1 Receptor Antagonist(IL-1ra)

作　　者：单清[1] 张杰[1] 任华[1] 王登龙[1] 姜严明[1] 钱焕文[1] 

机构地区：[1]军事医学科学院放射医学研究所,北京100850

出　　处：《工业卫生与职业病》2001年第2期71-74,共4页Industrial Health and Occupational Diseases

摘　　要：白细胞介素 - 1受体拮抗剂 (Interleukin - 1receptorantagonist,IL - 1ra)可阻断IL - 1在机体的免疫应答、感染、炎症反应和组织损伤中的作用。采用日本大耳白兔 ,造成角膜碱烧伤和激光烧伤模型 ,通过裂隙灯与病理组织学观察 ,角膜OD值与角膜上皮细胞活性测定 ,以及烧伤斑图像分析 ,系统观察研究LI - 1ra的治疗作用。结果表明 ,LI -Interleukin-1 receptor antagonist(IL-1ra)can interrupt effects of IL-1 in immunity response,infection,inflammation and tissue damage.In this study,the rabbits corneas were burned by alkali and laser,and treated with IL-1ra afterward.The curative effects were systematically observed by six items,including slit lamp observation,pathological findings,cornea OD values determination,activity detection of corneal epithelial cell,and analysis of the corneal burn images,The result indicated that IL-1ra might be eutherapeutic in cornea burn.

关 键 词：角膜烧伤 白细胞介素-1 受体拮抗剂 治疗 实验研究 

分 类 号：R779.105[医药卫生—眼科]