肝硬化和十二指肠溃疡患者血浆生长抑素及前列腺素E_2的变化和比较  

The Changes of Plasma Somatostatin and Prostaglandin E_2 in Patients with Hepatic Cirrhosis and Duodenal Ulcer

作　　者：高萍[1] 岳书勇 高伟[3] 杨敏 

机构地区：[1]中国人民解放军第254医院消化科,天津300142 [2]辽宁兴城武警8620部队医院 [3]天津大学电子工程学院 [4]武警医学院

出　　处：《天津医药》2001年第4期206-207,共2页Tianjin Medical Journal

摘　　要：目的:观察十二指肠溃疡及肝硬化患者胃肠粘膜保护性激素——血浆生长抑素(SS)和前列腺素E_2(PGE_2)含量的变化。方法:用放免法检测正常人20例,十二指肠溃疡(Du)和肝硬化患者各20例血浆SS和PGE_2含量。结果:血浆SS正常人为(39.5±9.3)μg/L,Du组为(24.1±4.4)μg/L,肝硬化患者为(20.3±7.6)μg/L。血浆PGE_2正常人为(2617±344)μg/L,Du组为(2102±507)μg/L,肝硬化患者为(1308±273)μg/L,Du及肝硬化病人血浆SS和PGE_2含量比正常人降低(均P<0.01)。结论:Du和肝硬化患者血浆SS和PGE_2含量均减少,后者比前者减少更显著,这可能是Du和肝硬化门脉高压性胃肠病发病的重要因素之一。To observe the changes of plasma somatostatin(SS)and prostaglandin μ (PGE2 )in patients with hepatic cirrhosis and duodenal ulcer. Methods:SS and PGE2 were measured in 20 duodenal ulcer patients,20 hepatic cirrhosis patients, and 20 healthy persons by radioactive immunoassay. Results:SS was (39.5 ± 9.3)μg/L, (24.1 ± 4.4)μg/L,and (20.3 ± 7.6)μg/L in healthy persons,duodenal ulcer and hepatic cirrhosis patients respectively. PGEj was (2 617 ± 344)μg/L, (2 102±507)jug/L,and (1 308±273)μg/L in healthy persons, duodenal ulcer and hepatic cirrhosis patients respectively. There was a significant difference in SS and PGEj between duodenal ulcer patients, hepatic cirrhosis patients, and healthy persons(P<0.01).Conclusion:The reduced SS and PGE^ may be important factors involved in duodenal ulcer and portal hypertensive gastropathy.

关 键 词：十二指肠溃疡 肝硬化 地诺前列酮 生长抑素 前列腺素E2 

分 类 号：R575.2[医药卫生—消化系统] R573.1[医药卫生—内科学]