初发精神分裂症患者外周血细胞免疫与原癌基因蛋白的表达  

The relationship of schizophrenic patient's lymphocyte immune indexes in peripheral blood cell to proto oncogene protein expression.

作　　者：许瑞环[1] 刘辉[2] 张洪德[1] 

机构地区：[1]深圳市龙岗中心医院,深圳518116 [2]大连医科大学免疫教研室

出　　处：《中国神经精神疾病杂志》2001年第2期93-94,共2页Chinese Journal of Nervous and Mental Diseases

基　　金：国家自然科学基金资助项目! (编号 :396 70 2 73)

摘　　要：目的　了解精神分裂症患者淋巴细胞核原癌基因 (FOS)蛋白表达与细胞免疫的关系。方法　检测精神分裂症 (SCH)外周血CD亚型淋巴细胞转化实验 (LTT) ,及正常人淋巴细胞在SCH血清作用下核FOS蛋白表达情况。结果　初发组淋巴细胞转化率明显降低 ,核FOS蛋白表达异常。结论　核FOS蛋白的异常表达可能与细胞免疫异常有关。Objective To discuss the relation of c FOS proteion expression in lymphocyte to its cellular immune. Methods To analyze the schizophrenic lymphocyte membrane markers CD + 3,CD + 4,CD + 8 and lymphocyte transforming test, and also examine c fos protein expression in PBC under SCH serum. Results The result was that LTT and c FOS protein were significantly decreased in drug free, first episode SCH. Conclusions The c FOS superexpression may be related to lymphocyte immune depression of SCH.

关 键 词：精神分裂症 原癌基因 CD4^+ CD8^+ 外周血 细胞免疫 

分 类 号：R749.3[医药卫生—神经病学与精神病学]