帕金森病患者血浆β-内啡肽含量的变化及其临床意义  

Study on Change of Concentration of β-endorphin in Plasma in Patients with Parkinson Disease and It's Clinical Significance

作　　者：张巍[1] 雷征霖[1] 谷玲[2] 李敬[2] 张延军[2] 蔡新霞[2] 张华丽[2] 杨春[2] 张万琴[3] 

机构地区：[1]大连医科大学第一临床学院神经内科,辽宁大连116011 [2]大连医科大学第一临床学院核医学科,辽宁大连116011 [3]大连医科大学基础部生理教研室,辽宁大连116011

出　　处：《中国神经免疫学和神经病学杂志》2001年第2期92-94,共3页Chinese Journal of Neuroimmunology and Neurology

摘　　要：目的　探讨帕金森病 (Parkinson disease,PD)患者血浆 β-内啡肽 (β-endorphin,β-EP)含量的变化及其临床意义。方法　采用放射免疫分析法测定 3 5例 PD患者血浆β-EP含量 ,并与 3 0例正常者作对照。结果　 PD患者血浆 β-EP含量较正常对照组明显降低 (P<0 .0 5) ;高龄、病情重及伴痴呆和抑郁的患者血浆 β-EP含量降低更显著 (P<0 .0 5)。结论　 PD患者血浆 β-EP含量显著降低 ,与 PD发病密切相关。高龄、病情重及伴痴呆和抑郁的患者血浆β-EP含量降低更明显 ,有助于对病情进展及预后进行评估。Objective To investigate change of concentration of β-endorphin (β-EP) in plasma in patients with Parkinson disease (PD) and evaluate the clinical significance. Methods The concentrations of β-EP in 35 PD patients were detected by radioimmune assay and compared with 30 normal controls. Results The concentration of β-EP in plasma in PD patients were significantly lower than that of normal controls;the concentration of β-EP in plasma was decreased more significantly in those patients who were older, severe, demential and depressive. Conclusions The significant decline of concentration of β-EP in plasma in PD patients might be closely related to it's pathogenesis. The concentration of β-EP in plasma was even significantly lower in older,severe,demential and depressive patients, so β-EP concentration can provide basis for evaluating severity ,progression and prognosis of disease in PD.

关 键 词：帕金森病 Β-内啡肽 预后 抑郁 痴呆 

分 类 号：R742.5[医药卫生—神经病学与精神病学]