奥曲肽与神经垂体素联合硝酸甘油治疗食管静脉曲张破裂出血的效果对比  

EFFECT OF OCTREOTIDE AND PITUITRIN ASSOCIATED WITH NITROGLYCERIN ON ESOPHAGEAL VARICEAL BLEEDING

作　　者：朱洪连 杜炜[1] 代云龙[1] 李健[1] 

机构地区：[1]单县中心医院消化科,山东省单县274300

出　　处：《齐鲁医学杂志》2001年第1期31-32,共2页Medical Journal of Qilu

摘　　要：①目的比较奥曲肽与神经垂体素联合硝酸甘油治疗食管静脉曲张破裂出血（ ＥＶＢ）的效果。②方法将４５例经胃镜证实的肝硬化ＥＶＢ病人随机分为奥曲肽组（ｎ＝２３）和联合组（ｎ＝２２），奥曲肽组给予奥曲肽治疗，联合组给予神经垂体素联合硝酸甘油治疗，通过胃管抽吸胃内容物观察止血情况，并记录药物的不良反应。③结果奥曲肽组１２及２４ｈ内的完全止血率分别为４７．８３％和７８．２６％，略高于联合组的４５．４５％和７２．７３％，但差异无显著性（ｘ２＝０．７６，１．１８，Ｐ＞０．０５）；两组病人治疗后７ｄ内的再出血率为 １１．１１％和 １８．７５％，差异亦无显著性（ｘ２＝２．１３，Ｐ＞０．０５）。两组不良反应发生率分别为８．７０％和３１．１８％，差异有显著性（ｘ２＝１９．１８，Ｐ＜０．０１），但均无严重不良反应。④结论奥曲肽与神经垂体素联合硝酸甘油治疗均能安全、有效控制ＥＶＢ．Objective To observe the efficiency of octreotide and pituitrin associated with nitroglycerin on esophageal variceal bleeding (EVB ). Methods 45 cirrhotic patients with EVB confirmed by endoscopy were randomly divided into 2 groups and administered with octreotide and pituitrin associated with nitroglycerin for 24h respectively. Tubes were placed in the stomach before the treatment. The duration of hemostatsis, rebleeding and side reactions were recorded. Results The hemostatic rate after 12 and 24h of the treatment in octreotide group was 47.83 % and 78.26% respectively, it was higher than that in combined group (45.45%, 72.73% ), but there was no significant difference in the rate of hemostatsis and rebleeding between the two groups (x2＝0.76, 1.18, P>0.05 ). The rate of side reactions in octreotide and combined groups was 8.70% and 31.18% respectively. There was significant difference (x2＝19.18 P<0.01), but no severe side reactions were found. Conclusion Both the therapy of octreotide and pituitrin associated with nitroglycerin can safely and effectively control EVB.

关 键 词：食管胃静脉曲张 出血 奥曲肽 神经垂体素 硝酸甘油 联合药物治疗 

分 类 号：R571.305[医药卫生—消化系统]