胃内pH变化与消化性溃疡出血治疗效果的临床研究  

Study on the relationship between intragastric pH and therapeutic resulte of peptic ulcer hemorrhage

作　　者：殷新光[1] 杨志宏[1] 顾金森[1] 董莲珠[1] 

机构地区：[1]浙江省嘉兴市第二医院,314000

出　　处：《中华消化内镜杂志》2001年第1期12-14,共3页Chinese Journal of Digestive Endoscopy

摘　　要：目的通过不同抑酸药物的应用，使胃内产生不同的 pH值 ,探讨胃内 pH与消化性溃疡出血治疗效果的关系。方法将 35例消化性溃疡伴出血患者，随机分 3组，分别给予奥美拉唑、泰胃美、止血药物静滴治疗。持续监测 24 h胃内 pH动态变化情况，同时临床观察三组治疗的止血效果。结果胃内平均 pH值，奥美拉唑 80mg/d为 6.07± 1.09、泰胃美 1200mg/d为 4.39± 1.92、对照组为 2.19± 1.74。相应止血有效率分别为 91.6％， 57.4％， 11.1％。各组在不同 pH条件下的止血有效率比较，差异均有显著性。结论胃内 pH的变化可影响到消化性溃疡出血治疗的效果，二者呈正相关，胃内 pH持续稳定在较高的数值，止血治疗效果最好。Objective To investgate the relationship between intragastric pH and hemostatic efficacy of peptic ulcer hemorrhage by various antiacid drugs administered intravenously. Methods Thirty－ five patients with peptic ulcer hemorrhage were divided into three groups at random, and were treated respectively by intravenous dripping omeprazole 40mg q12h,tagamet 400mg q8h and common hemostatic drugs for control,at the same time 24－ hr intragastric pH were monitored continuously and therapeutic efficacy was observed. Results Mean intragastric pH in omeprazole 80mg/d group,tagamet 1200mg/d group and hemostatic drugs groups were 6.07± 1.09, 4.39± 1.91,and 2.19± 1.74 respectively.The relative hemostatic efficiency were 91.6， 57.4％ and 11.1％ respectively. Difference of effective rates among all the groups is statistically significant.Conclusion Intragastric pH value correlates positively with the effectivenese of peptic ulcer hemorrhage. Continuous high intragastric pH level will lead to better treatment results.

关 键 词：消化性溃疡 出血 胃内PH值 

分 类 号：R573.2[医药卫生—消化系统]