Barrett食管的临床研究  

Barrett’ s esophagus: clinical study

作　　者：张军[1] 张莎莎[1] 罗金燕[1] 龚均[1] 王学勤[1] 左爱丽[1] 

机构地区：[1]西安医科大学第二附属医院消化内科,710004

出　　处：《中华消化内镜杂志》2001年第1期15-18,共4页Chinese Journal of Digestive Endoscopy

基　　金：卫生部科学研究基金资助!( No 98- 2- 209)

摘　　要：目的研究 Barrett食管（ Barrett’ s Esophagus， BE）在国人内镜下的发病状况和发病特点，并初步探讨其可能的发病机制。方法应用胃镜检查及灌注式食管测压方法研究了 61例 BE与 126例反流性食管炎 (RE)患者在临床表现及食管运动功能方面的区别。结果 BE组与 RE组在各项反流症状上无区别（ P>0.05）；但 BE组合并食管炎的情况少，程度也轻（ P< 0.001）；两组合并消化性溃疡的发生率相似（ P>0.05）； BE组较无并发症的 RE组胃内压力高（ P< 0.05）；其它各项食管测压结果两组无区别（ P>0.05）；结论 BE在中国人中的发病率和发病特点与西方人有不同之处有待于今后更深入系统的研究 ;食管运动功能缺陷可能不是导致中国人群中 RE发展为 BE的主要原因。Objective To explore the endoscopic features and possible pathogenesis of Barrett’ s esophagus (BE). Methods A total of 61 patients with BE and 126 cases with reflux esophagitis (RE) was enrolled in the study. Their clinical characteristics and motor functions were observed and tested by endoscopy and manometry. Results The manifestations of reflux esophagitis and occurrence of peptic ulcer in cases with BE were in parallel to those with RE (P >0.05), but the frequency and intensity of macroscopic esophagitis of BE were significantly milder than those of RE (P< 0.001). No statistical difference was found in most indices of esophageal motor function between two groups (P >0.05) except that a higher intragastric pressure was recorded in patients with BE. Conclusion The esophageal motor dysfunction is unlikely the main factor in the genesis of BE .

关 键 词：BARRETT食管 反流性食管炎 食管测压 

分 类 号：R365[医药卫生—病理学]