诊断级超声对人孕早期绒毛组织的化学影响  

Effect of diagnostic ultrasound on histochemistry in human villus

作　　者：崔运河[1] 孙凤兰[2] 王强[1] 夏敏[3] 刘香环[3] 王乃辉[3] 

机构地区：[1]山东济宁医学院,272013 [2]山东省济宁市中区妇幼保健院 [3]山东省济宁市第二人民医院

出　　处：《中国全科医学》2001年第4期275-276,共2页Chinese General Practice

基　　金：山东省教委资助课题 !(G97K2 1)

摘　　要：目的　探讨诊断级B超对人胚胎发育的安全性。方法　将 12 0名孕 6～ 8周拟行人工流产的孕妇随机分成 6个组 (Ⅰ～Ⅵ ) ,其中Ⅰ为正常对照组 ,Ⅱ～Ⅴ依次为辐照 5分钟、 10分钟、 2 0分钟、 30分钟后于 1小时内取绒毛检测组 ,Ⅵ为辐照 30分钟后于 7～ 10天取绒毛检测组。分别检测各组绒毛组织的化学变化。结果诊断剂量超声辐照 2 0分钟可致人体宫内绒毛组织发生化学变化。丙二醛 (MDA)值随超声剂量增加而升高(PⅠ -Ⅲ >0 0 5 ,PⅠ -Ⅳ <0 0 1,PⅠ -Ⅴ <0 0 5 )而超氧化物歧化酶 (SOD)及谷胱甘肽过氧化物酶 (GSH - px)活性随超声辐照剂量增加而下降 (PⅠ -Ⅲ >0 0 5 ,PⅠ -Ⅳ <0 0 1,PⅠ -Ⅴ <0 0 1)。对照组与Ⅵ组比较P >0 0 5 ,提示损伤作用是可逆性的。结论　诊断超声辐照 2Objective The effects of diagnostic ultrasound on human embryos in early pregnancy were investigated.Methods The villous taken from 120 normal pregnant whose plan induced abortion in early pregnant women were divided into six groups:Ⅰ(control group),Ⅱ,Ⅲ,Ⅳ,Ⅴand Ⅵrespectively exposed for 5,10,20,30 minutes lipid peroxides change detected after 1 hour,Ⅵ for 30 minutes, lipid peroxides change detected after 7～10 days.Results Exposure of conventional diagnostic ultrasound for 20 minutes could result in lipid peroxide change of human villous cells. The value of MDA was increased with ultrasound exposure time(P Ⅰ-Ⅲ >0 05,P Ⅰ-Ⅳ <0 01,P Ⅰ-Ⅴ <0 05=,while the level of SOD and GSH-px was decreased with ultrasound exposure dosage(P Ⅰ-Ⅲ >0 05,P Ⅰ-Ⅳ <0 01,P Ⅰ-Ⅳ <0 01=.Such changes became normal after 7～10 days(P>0 05).Conclusion It is latency harm that diagnostic ultrasound more than 20 minutes could result in lipid peroxide change of human villous cells.

关 键 词：诊断级超声 绒毛 脂质过氧化 组织化学 胚胎发育 影响 安全性 

分 类 号：R445.1[医药卫生—影像医学与核医学] R321[医药卫生—诊断学]