重离子与X射线沿水介质入射深度诱导癌细胞失活的比较  

Comparison of the induced inactivation in cancer cells between heavy ions and X-rays along penetration depth in water

作　　者：李文建[1] 卫增泉 周光明[1] 王菊芳[1] 李强[1] 颉红梅[1] 党秉荣[1] 蔡喜臣[1] 何静[1] 梁克 沈瑜 

机构地区：[1]中国科学院近代物理研究所,兰州730000 [2]中国医学科学研究院肿瘤研究所,北京100021

出　　处：《核技术》2001年第4期305-308,共4页Nuclear Techniques

基　　金：甘肃省自然科学基金 !(SJ970 6 0 8);中国科学院院长特别支持基金!(TB990 6 0 1)资助

摘　　要：采用Hela、B16两种细胞分别研究了X射线和重离子在水介质中入射的深度与相应细胞的存活率 (1-失活率 )。结果表明 :X射线与重离子在入射深度与细胞存活关系上有明显不同的变化规律。X射线的入射深度与其细胞存活率呈高度正相关性 ,r =0 .92 ;而重离子通过路径的细胞损伤率较小、且有一个细胞存活较高的坪区 (86 %— 92 % ) ,到射程末端细胞损伤率剧增 ,出现倒Bragg峰。提示The relationship between penetration depth of X-rays and heavy ions in water and corresponding cell survival fraction, with Hela and B 16 cells, were studied, respectively. The results showed there were significantly different variation rules for X-rays and heavy ions in correlation between depth and cell survival. The relationship between depth and survival fraction for X-rays displayed highly positive correlation, i. e. r =0.92. However, heavy ions had less damage effect on cells and existed a plateau region with 80%—92% survival fraction following passing through the cells; while at the end of their range, cells were greatly damaged and their survival fraction decreased dramatically, presenting an inverse Bragg peak. It is suggested that tumor therapy with heavy ions have a better curing efficiency compared to X-rays.

关 键 词：重离子 X射线 癌细胞 入射深度 细胞失活 肿瘤 放射治疗 

分 类 号：R730.55[医药卫生—肿瘤]