人胰岛素样生长因子受体及其生长因子在原发性肝癌中同时过量表达  

SIMULTANEOUS OVEREXPRESSION OF INSULIN-LIKE GROWTH FACTOR Ⅱ(IGF-Ⅱ)AND IGF Ⅱ RECEPTOR GENES IN HUMAN PRIMARY HEPATIC CANCER

作　　者：周筱梅[1] 陈渊卿[1] 蒋惠秋[1] 钱连芳[1] 徐国威[1] 顾健人[1] David Shafritz 

机构地区：[1]上海市肿瘤研究所癌基因与相关基因国家重点实验室 [2]美国纽约Albert

出　　处：《肿瘤》1991年第6期241-242,F003,共3页Tumor

基　　金：美国Albert Einstein大学肝癌研究中心的合作项目

摘　　要：人胰岛素样生长因子II(IGFⅡ)是一种胚胎性生长因子,与肝、肌、肾细胞生长有关,但其详细功能仍不明,我们曾于1988年报道了人原发性肝癌中IGFⅡ的过量表达,以后又进行了IGFⅡ基因工程的表达研究。This is the first report about the simultaneous overexpression of both Insulin-like growth factor Ⅱ (IGF Ⅱ) and its receptor(IGF Ⅱ R) at mRNA level in human primary hepatic cancers (PHC). In 10 PHC samples from China, IGF Ⅱ and IGF Ⅱ R were both over-expressed, whearas only a background signal was detected in normal liver. In 5 pairs of PHO and oancer adjacent non-tumours liver tissues from South Africa, IGF Ⅱ and IGF Ⅱ R were also overexpressed in PHC mRNA expression of IGF Ⅱ in all 5 cases and IGF Ⅱ R in 4 of 5 oases were higher in cancer than in non-cancerous liver tissue. These results strongly implicate the autocrine and paracrine mechanism in auto- nomous growth of PHC.

关 键 词：原发性肝癌 人胰岛素样生长因子受体 基因过量表达 

分 类 号：R735.7[医药卫生—肿瘤]