东莨菪碱对大脑皮层癫痫放电影响的动物实验研究  

Investigation on Effect of Scopolamine on Epileptiform Discharges of Cerebral Cortex of Animal

作　　者：韩丹[1] 张桂林[1] 

机构地区：[1]湖北医学院生理教研室

出　　处：《湖北医学院学报》1991年第4期304-307,共4页

摘　　要：本工作目的在于研究胆碱能受体阻断剂东莨菪碱(scopolamine)能否纠正大脑皮层癫痫放电.实验用大鼠31只,80万单位青霉素诱发急性全身性癫痫模型(n=19,ip),170单位青霉素直接施加在大鼠大脑皮层上诱发癫痫放电(n=12).全身性癫痫模型的主要放电形式有:阵发性、持续性多棘波连续发放,棘慢波综合,其放电振幅一般为180～800μV,侧脑室注射“莨菪化”剂量东莨菪碱4.5～12μg(n=14)明显压抑大脑皮层多棘波型癫痫放电振幅(10/14),也可以使多棘波型癫痫放电向高波幅慢波转化,以及减少异常放电指数.侧脑室注射相同剂量生理盐水对癫痫放电无明显影响(n=5).大脑皮层局部用青霉素主要诱发高波幅尖波型癫痫放电,腹腔注射东茛菪碱0.3mg/kg 明显降低癫痫放电频率,但对其振幅的影响较弱.结果提示:东莨菪碱能够压抑大脑皮层癫痫放电,但不能完全纠正之.We examined whether scopolamine could block epileptiform discharges of cerebral cortex of 31 rats,we found that:(1)the voltage of polyspikes burst induced by systemic use of high dose penicillin was significantly depressed by scopolamine(ip,4.5-12μg),(2)rhythmic slow waves could be e- voked by scopolamine.Frequency of high sharp waves induced by penicillin(170U)over surface of cerebral cortex became low after administration of scopolamine(0.3mg/kg,ip).The results showed that antagonist of muscarine receptor—scopolamine could retard,but not completely block epileptiform discharges induced by penicillin.

关 键 词：东莨菪碱 药效学 癫痫 青霉素 大鼠 动物实验 大脑皮层放电 

分 类 号：R742.1[医药卫生—神经病学与精神病学] R971.92[医药卫生—临床医学]