头低位-6°卧床生理变化动态特征  

Investigation of Dynamic Characteristics of Main Physiological Parameters During Bed Rest Test

作　　者：阎晓霞[1] 余和琫 刘振秀[1] 杨玉华[1] 王秀荣[1] 吴建平[1] 

机构地区：[1]航天医学工程研究所,北京100094

出　　处：《航天医学与医学工程》1991年第4期259-267,共9页Space Medicine & Medical Engineering

摘　　要：观察了6名19～21岁男性健康受试者,头低位-6°卧床8天生理生化指标昼夜节律特性的变化。结果:心输出量、脉压和去甲肾上腺素日平均水平显著下降;外周阻力、尿中的Na^+、K^+和皮质醇含量显著增加。这表明,卧床使心血管功能减弱,交感神经兴奋性下降,水盐代谢紊乱。从心输出量和去甲肾上腺素之间的中度正相关关系,可以推测去甲肾上腺素对卧床期心输出量的调节可能起着重要作用。Six healthy male volunteers aged 19—21 were selected as test subjects. The schedule of experiments included a 3—day control period ( pre—HDT), a 8—day bed rest period with head down tilt of —6°(HDT—6°) and a 5—day recovery period (post—HDT). Physiological parameters (SV, CO,HR, BP, TFI, EVI, LVET) were measured four times and norepinephrine (NE), epinephrine (E), potassium (K^+), sodium (Na^+) and cortisol excretion in urine were assayed six times daily in the experiment. The results indicated that SV, CO, pulse pressure and NE excretion decreased significantly and peripheral resistance, K^+, Na^+ and cortisol excretions increased markedly during HDT—6°. Circadian rhythmic changes of the cardiovascular and biochemical parameters were also observed. The fact that there was a positive correlation with medium significance between cardiac output and NE reflects that NE might play an important role in the control of CO during bed rest.

关 键 词：卧床试验 生理反应 昼夜节律 失重 

分 类 号：R852.22[医药卫生—航空、航天与航海医学]