复方骨质增生贴剂体外透皮速率测定和体外释放研究  

Determination of in vitro Percutaneous Rate and in vitro of Release of Compound Patch of Hyperosteogeny

作　　者：许英爱[1] 戈延茹[2] 王雅君[1] 金瑛[1] 李凤龙[2] 

机构地区：[1]第四军医大学吉林军医学院,吉林吉林132013 [2]延边大学医学院,吉林延吉133000

出　　处：《中成药》2001年第4期237-240,共4页Chinese Traditional Patent Medicine

摘　　要：目的 :研究复方骨质增生贴剂 (CPH)的经皮吸收的可行性。方法 :采用高效液相色谱法测定透皮接受液和释放接受液中指标成分—阿魏酸的浓度。结果 :体外透皮实验和体外释放实验结果表明 :阿魏酸在 2 4h内以一定的速率 0 .2 142μg·cm-2 ·h-1恒速渗透 ,其释放符合Higuchi方程。此外 ,该贴剂的体外释放速率为 14.5 3μg·cm-2 ·h-1/ 2 。结论Objective: To study the feasibility of percutaneous absorption of Compound Patch of Hyperosteogeny(CPH). Methods: The content of ferulic acid,an index composition in percutaneous receptor fluid and release receptor fluid were determined by HPLC.Results: The results of in vitro transdermal delivery experiment and in vitro release experiment showed that ferulic acid permeated at the constant speed of 0.2142μg·cm -2 ·h -1 in 24 hours and its release coincided with Higuchi Equation.Futhermore,the release rate was 14.53μg·cm -2 ·h -1/2 . Conclusion: CPH is a skeleton controlledtransdermal delivery system whose permeation speed is limited by skin.

关 键 词：骨质增生 透皮吸收 阿魏酸 高效液相色谱法 速率 复方骨质增生贴剂 实验 体外释放 

分 类 号：R274.91[医药卫生—中西医结合] R285.5[医药卫生—中医骨伤科学]