益脑宁对大鼠的药效学研究  

Pharmacodynamic Study of Yinaoning on Rats

作　　者：吴浩[1] 袁伯俊[1] 刘俊平[1] 

机构地区：[1]第二军医大学,上海200433

出　　处：《中成药》2001年第4期271-273,共3页Chinese Traditional Patent Medicine

摘　　要：目的 :观察益脑宁对大鼠的主要药效作用。方法 :大鼠预防性口服益脑宁 0 .4375～ 1.75g/kg 7d ,采用大鼠急性血瘀模型和大鼠脑缺血模型。结果 :益脑宁能明显降低血瘀模型大鼠的全血粘度、血浆粘度 ,缩短体外血栓形成的长度 ,减轻血栓干、湿重量 ;明显降低脑缺血大鼠的脑指数 ,高剂量组伊文思蓝含量明显减少 ,减轻脑神经细胞变性。作用与益脑宁片相似 ,且均有一定的量效关系。结论 :益脑宁对大鼠“血瘀”Objective: To observe the main pharmacodynamic effects of Yinaoning (YNN) on acute blood stasis rats and cerebral ischemia rats. Methods: Rats were prevented by the oral administration of YNN (0.4375～ 1.75g/kg once daily for 7 days. The acute blood stasis model and cerebral ischemaed model were used. Results: YNN could decrease the blood viscosity and plasma viscosity, shorten the length of in vitro thrombus, abate the wet and dry weights of thrombus in the acute blood stasis model group. It decreased the brain index significantly in the cerebral ischemia model group. The high dose of YNN could decrease the level of Evans blue obviously and reduce the degeneration of cranial nerve cells. These effects were similar to those of YNN Tablets and were dose dependent. Conclusion: YNN is effective for acute blood stasis rats and cerebral ischemaed rats.

关 键 词：益脑宁 血瘀模型 脑缺血 大鼠 

分 类 号：R285.5[医药卫生—中药学] R277.733.1[医药卫生—中医学]