胶原聚合物生物相容性研究  

Study on biocompatibility of collagen copolymer

作　　者：辜臻晟[1] 盛耀华[1] 王丽天[1] 祝肇荣[1] 李增琦[1] 高金榜[1] 

机构地区：[1]上海第二医科大学附属新华医院眼科,200092

出　　处：《眼科新进展》2001年第2期81-83,共3页Recent Advances in Ophthalmology

基　　金：上海高等学校科学技术发展基金资助

摘　　要：目的　评定胶原聚合物为主体的 ICL 在动物体内的生物相容性。方法　分别应用胶原材料进行以下生物学测试 :(1)细胞毒性试验 (细胞增殖度法 ) ;(2 )致敏试验 ;(3)热原试验 ;(4 )皮下植入试验。实验数据根据标准进行分析和评估。结果　细胞毒性试验、过敏试验和皮下植入试验 ,胶原试品反应均为 0～ 1级。热原试验中胶原试品个体升温均在0 .6℃以下 ,升温总值在 1.4℃以下。结论　材料生物学测试结果显示胶原聚合物具有高度生物相容性 ,是设计制造 ICLObjective To evaluate compatibility of ICL made of collagen in animal bodies.Methods Collagen was used to perform the following biological tests:(1)cytotoxicity test; (2)anaphylaxis test; (3)pyrogenic reactions test; (4)subcutaneous implant test. The data were analyzed and evaluated by criterion.Results Reaction scales of collagen in cytotoxicity, anaphylaxis and subcutaneous implant tests were 0 to 1 level. In pyrogenic reactions, the value of each rabbit's increasing temperature in collagen group was below 0.6℃ and the total value was below 1.4℃.Conclusion Results of material biological evaluation tests demonstrate that this copolymer is of high biocompatibility and can become an ideal material for ICL.

关 键 词：胶原 眼内接触镜 生物相容性 聚合物 

分 类 号：R778.3[医药卫生—眼科] R318.08[医药卫生—临床医学]