肝硬化鼠肝移植后早期全身和内脏血流动力学的变化  

Early alterations of systemic and splanchnic hemodynamics after orthotopic liver transplantation in cirrhotic rats

作　　者：曹晖[1] 吴志勇[1] 张效杰[1] 张海婴[1] 陈治平[1] 邝耀麟[1] 

机构地区：[1]上海第二医科大学附属仁济医院普外科,200001

出　　处：《中华普通外科杂志》2001年第4期225-227,共3页Chinese Journal of General Surgery

基　　金：上海市自然科学基金资助项目 !(97ZB14 0 19)

摘　　要：目的　观察正常鼠肝移植以及肝硬化鼠肝移植术后早期全身和内脏血流动力学的变化。方法　实验动物随机分为正常鼠 (NL ,10只 )、肝硬化鼠 (IHPH ,10只 )、正常鼠肝移植 (NL OLT ,9只 )、肝硬化鼠肝移植 (IHPH OLT ,16只 )组。分别采用放射性微球法行血流动力学研究。结果　NL OLT鼠绝大多数血流动力学参数与NL鼠比较差异无显著意义。IHPH及IHPH OLT 3d ,7d组心输出量和内脏血流量增加 ,平均动脉压、周围血管总阻力和内脏血管阻力降低。内脏血流动力学紊乱较全身明显。Objective The purpose of this study was to investigate early alterations of systemic and splanchnic hemodynamics after orthotopic liver transplantation (OLT) in normal and cirrhotic rats. Methods Male SD rats were divided into 4 groups: normal controls (NL, n =10), intrahepatic portal hypertension (IHPH, n =10) induced by CCl 4, normal rats with OLT (NL OLT, n =9) and IHPH rats with OLT (IHPH OLT, n =16). Radioactive microsphere method was used for hemodynamic study.[WT5”HZ] Results Increased cardiac output and splanchnic blood flow, decreased mean arterial blood pressure, total peripheral vascular resistance and splanchnic vascular resistance were found in IHPH, IHPH OLT at day 3, and IHPH OLT at day 7 in cirrhotic rats. The magnitude of hyperhemodynamic alterations was in the order of IHPH>IHPH OLT (day 3) >IHPH OLT (day 7) rats. Moreover, the derangement of splanchnic hyperhemodynamics was more significant than that of systemic hyperhemodynamics. Conclusions The results demonstrated that systemic and splanchnic hyperkinetic abnormalities seen in early liver transplantation may come from the pretransplant pathophysiologic status in cirrhotic rats.

关 键 词：血液动力学 肝硬化 肝移植 门脉高压症 鼠 

分 类 号：R575.2[医药卫生—消化系统]