大鼠全脑缺血再灌注所致肺损伤的发病机制研究  

The mechanism of the lurg injury after global ischemia in rats

作　　者：王钧[1] 于化鹏[1] 杨振峰[1] 蒋小忠[1] 王富强[1] 

机构地区：[1]解放军第一军医大学珠江医院,广东广州510282

出　　处：《现代康复》2001年第4期42-43,共2页Modern Rehabilitation

摘　　要：目的脑缺血所致肺的病理改变以及 SP、 SP受体在肺内分布的变化及探讨所致肺损伤的有关机制。方法 SD大白鼠 12只，分为对照组（ C组 , n=6）和缺血再灌注组 (I组 , n=6)。 C组动物处死后，取肺组织，冰冻切片。 I组动物造成全脑缺血再灌流模型后，冰冻切片。分别做 HE染色及免疫组织化学染色。结果 C组动物 SP阳性纤维分布于气管黏膜层和柱状细胞层， I组动物肺组织中 SP分布明显减少。血管上皮细胞层、内皮细胞层和气管黏膜下可见 SPR阳性细胞。 I组动物肺组织 SPR在肺内分布几乎消失。结论在大鼠全脑缺血再灌注后，肺内出现明显炎性病变。 SPR表达降低， SP含量明显减少。Objective To explore the mechanism of the lung injury induced by transient global ischemia ,the distribution of substance P(SP) and SP receptor in rats lung were observed.Method 12 rats were exploited.They were divided into two groups, the global ischemia group(I group,n=6) and control group(C group, n=6).Two group animals were slaughtered after given anesthesia.The lung frozen sections were collected and stained by the methods of hematoxylin and eosin(HE) and immunohistochemistry.Result a decreased positive immunoreactivity for SP and SP receptors was found in the bronchus mucous membrane and the epithelial and endothelial cell of blood vessels after global ischemia.Conclusion Global ischemia can induce inflammation and a significant decrease in distribution of SP and SP receptor in rats lung .

关 键 词：脑缺血再灌注 肺 P物质 受体 

分 类 号：R743.302[医药卫生—神经病学与精神病学]