2型DM合并脑梗塞与载脂蛋白、脂蛋白(a)关系的研究  

A Study on the Relationship between Cerebral Infarction and Apo, Lp(a) in Type 2 Diabetes Patients

作　　者：王鹏华[1] 靳建鸣[2] 孟庆和[2] 宁宪嘉[3] 刘玉茹[4] 徐磊[5] 

机构地区：[1]天津医科大学代谢病医院,天津300070 [2]天津医科大学公共卫生学院,天津300070 [3]天津医科大学总医院,天津300052 [4]天津市民族医院,天津300122 [5]天津市第三中心医院,天津300170

出　　处：《中国慢性病预防与控制》2001年第2期67-69,共3页Chinese Journal of Prevention and Control of Chronic Diseases

摘　　要：目的探讨载脂蛋白 (Apo)和脂蛋白 (a)〔L p(a)〕与 2型 DM合并脑梗塞的关系。方法运用配比的病例对照研究方法 ,使用 L ogistic回归模型进行分析。结果以其他病人作为对照 ,Apo和 L p(a)与 2型 DM合并脑梗塞有关 ;2型 DM病人作为对照仅发现 L p(a)与 2型 DM合并脑梗塞有关。经以 2型 DM为对照人群归因危险比(PARP)分析 ,L p(a)的 PARP高达 75 .6 7%。结论 L p(a)是 2型 DM合并脑梗塞的独立危险因素。为了降低 2型DM合并脑梗塞的危险性 ,应注意控制 L p(a)Objective The cerebral infarction, a common acute cerevascular disease, is one of the main complication of type 2 diabetes mellitus (T2DM). We studied on the relationship of Apo, Lp(a) and cerebral infarction in T2DM patients. Methods A pair matched case control study was carried out. Data was analyzed by Logistic regression. Results Apo and Lp(a) were related to cerebral infarction in T2DM compared with other kind of patients. While compared with T2DM patients, only Lp(a) was related to T2DM complication cerebral infarction. The results showed that the PARP of Lp(a) was 75 67%. Conclusion Lp(a) was an independent risk factors for T2DM patients complicated with cerebral infarction. Controlling the level of serum Lp(a) would decrease the risk of cerebral infarction in T2DM patients.

关 键 词：2型DM 脑梗塞 载脂蛋白 脂蛋白(a) 病例对照研究 

分 类 号：R743.33[医药卫生—神经病学与精神病学]