P^(53)andc-myc蛋白在食管癌及癌前病变中的表达意义  

Significance of P^(53) and c-myc protein expression in precancerous lesions and carcinoma of esophagus

作　　者：赵光明[1] 张龙功 赵卫星[1] 秦志强[1] 张丽娟[1] 付佶 张明彩[1] 

机构地区：[1]新乡医学院一附院病理科,河南卫辉453100 [2]河南邓州市卫生职业中专,河南邓州473000

出　　处：《新乡医学院学报》2001年第1期10-11,共2页Journal of Xinxiang Medical University

基　　金：河南省科技攻关项目! (96 12 0 0 10 2 )

摘　　要：目的　探讨P53 及c -myc蛋白在食管癌及癌前病变中的表达及意义。方法　应用免疫组化SP法检测P53 及c -myc在 6 0例食管癌及 33例非典型增生中的表达。 结果　P53 及c -myc蛋白分别在食管癌与非典型增生I～II级中表达有显著差异 (P <0 .0 5 ) ;在食管癌与非典型增生III级表达中无显著差异 (P >0 .0 5 )。结论　P53 及c -myc蛋白异常表达 ,可为食管癌和癌前病变界限的划分提供参考依据。Objective To investigate the significance of P 53 and c-myc protein expression in precancerous lesions and cancers of esophagus. Method TheP 53 and c-myc protein expression were determined by using SP immunohistochemistry staining method. Result Significant differences were detected between esophageal cancer group and each dysplasia group (P<0.05) in both P 53 and c-myc oncoprotein expression, except for dysplasia grade Ⅲ (P>0.05). Conclusion The abnormal expression of P 53 and c-myc protein may offer a reference for the grading and classification of esophageal carcinoma and precancer lesions.

关 键 词：食管癌 癌前病变 P^53基因蛋白 C-MYC基因蛋白 

分 类 号：R735.102[医药卫生—肿瘤]