ClC-1氯离子通道的非均衡性门控及其对细胞外氯离子浓度的依赖性  

Nonequilibrium gating of ClC-1 chloride channel and its dependence on extracellular chloride concentration

作　　者：张晓东[1] 臧益民[1] 周士胜[1] 

机构地区：[1]第四军医大学生理学教研室,陕西西安710032

出　　处：《心脏杂志》2001年第2期87-89,共3页Chinese Heart Journal

基　　金：国家自然科学基金资助项目!( No.3 9770 2 81)

摘　　要：Cl C- 1是一种具有电压依赖门控特性的氯离子通道。但这种通道的门控机制与其他电压门控的阳离子通道有很大的差别。为探讨 Cl C- 1离子通道的门控机制 ,本文应用爪蟾卵母细胞异源性表达野生型 Cl C- 1氯离子通道 ,并通过改变细胞外氯离子浓度 ,对其门控机制进行了研究。结果表明 ,Cl C- 1氯离子通道的门控具有对电压和氯离子浓度的双重依赖性。这提示一种非均衡性的门控机制。ClC 1 is a voltage dependent chloride channel. But its gating mechanism is different from the voltage dependent cation channels. ClC 1 gating mechanism is discussed in this paper by heteroexpression of this channel in Xenopus oocytes and by changing extracellular chloride concentration. It is concluded that ClC 1 gating is both voltage and chloride concentration dependent which suggests a nonequilibrium gating mechanism.

关 键 词：ClC-1 离子通道 氯 门控 爪蟾卵母细胞 骨骼肌 平滑肌 

分 类 号：R337.5[医药卫生—人体生理学]